Results 131 to 140 of about 16,357 (238)

A formulation and a metaheuristic approach for the clustered vehicle routing problem with d‐relaxed priority rule

open access: yesInternational Transactions in Operational Research, Volume 33, Issue 6, Page 3714-3743, November 2026.
Abstract This paper investigates an extension of the vehicle routing problem in which, in addition to minimizing the distance traveled, the sequencing of customer visits is subject to precedence constraints that impose visiting priorities among customers.
Eduardo dos Santos Teixeira   +1 more
wiley   +1 more source

Beyond Pigment Loss: Integrating Clinician‐Reported Outcomes, Patient‐Reported Outcomes, and Digital Biometrics to Quantify Vitiligo Morbidity

open access: yesDermatological Reviews, Volume 7, Issue 5, October 2026.
ABSTRACT Background Vitiligo is an autoimmune depigmenting disease with multiple facets to disease severity. Accurate assessment of severity and therapeutic response is essential for both clinical care and research. Methods This narrative review summarizes outcome measures for assessing different aspects of vitiligo severity, including extent, activity,
Shrruthi Velavan, Vishal Gupta
wiley   +1 more source

Severity of Cardiovascular Autonomic Neuropathy Is Linked to Increasing Levels of Circulating Proinflammatory Cytokines

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8847-8860, October 2026.
ABSTRACT Aims Cardiovascular autonomic neuropathy (CAN) is a severe form of diabetic neuropathy affecting approximately one in five people with diabetes and is a major predictor of cardiovascular mortality. Low‐grade inflammation may contribute to CAN development, but the exact inflammatory factors associated with CAN remain unclear.
Michelle Damgaard   +9 more
wiley   +1 more source

Impact of simulated drought and cover crop mixtures on subsequent spring wheat yield

open access: yesAgrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Cover crops (CCs) are promoted as a mechanism for reducing soil erosion, enhancing soil fertility, and improving diversity in agricultural systems, but in drier climates, there are concerns about their impact on soil water availability for the subsequent crop.
Jonathan J. Halvorson   +5 more
wiley   +1 more source

Cover crop and termination date effects on wheat forage biomass, nutrient content, and profitability

open access: yesAgrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Cover crops are being encouraged due to benefits to soil health and ecosystem services, but they could negatively affect subsequent forage production and system profitability in regions with limited water availability. The objectives of this study were to determine the effects of cover crop treatment and termination date on wheat (Triticum ...
Yuan Zhang   +3 more
wiley   +1 more source

Effects of Transcutaneous Vagus Nerve Stimulation on Cerebral Perfusion and Cognitive Function Under Simulated High‐Altitude Hypobaric Hypoxia

open access: yesBrain and Behavior, Volume 16, Issue 9, September 2026.
This graphical abstract illustrates the study design of this research. Participants were divided into tVNS (n = 23) and control (n = 20) groups. Baseline MRI was acquired before chamber entry. Biochemical and cognitive tests were performed at three phases: pre‐chamber, in‐chamber (with tVNS for the intervention group), and post‐exit. Follow‐up MRI were
Xiaojun Yu   +14 more
wiley   +1 more source

Lidocaine Combined With Platelet‐Rich Plasma for Stellate Ganglion Block in Chronic Migraine: A Multicenter, Prospective, Propensity Score‐Matched Cohort Study

open access: yesBrain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Objectives To explore the association of stellate ganglion block with platelet‐rich plasma plus lidocaine with clinical outcomes in adults with chronic migraine, in comparison to lidocaine alone. Methods This multicenter prospective exploratory study enrolled 200 adults with chronic migraine scheduled for stellate ganglion block across three ...
Lu Liu   +5 more
wiley   +1 more source

Neural Circuit Mechanisms of Disorders of Consciousness and Potential Therapeutic Targets of Brain Stimulation

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review integrates three hierarchical frameworks—ascending reticular activating system (ARAS), mesocircuit hypothesis, and intrinsic connectivity networks (ICNs)—to update the neural mechanisms of disorders of consciousness (DoC). We highlight emerging evidence for glutamatergic ARAS pathways, a bidirectional GPi–GPe mesocircuit regulating ...
Yichen Zhou   +7 more
wiley   +1 more source

Advances in Targeting Central Cholinergic Dysfunction for Neurodegenerative Diseases: From Pharmacotherapy to Neuromodulation

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review charts the evolution of cholinergic therapies for neurodegenerative diseases—from classical acetylcholinesterase inhibitors (AChEIs) providing symptomatic relief to precision multi‐target drugs and neuromodulation (VNS, DBS, NIBS) that restore dysfunctional circuits. Emerging gene therapy, cell regeneration, and advanced cholinergic imaging
Lei Lei   +4 more
wiley   +1 more source

Neurocardiology: Brain–Heart Interactions in the Heart

open access: yesMedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang   +3 more
wiley   +1 more source

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