Results 1 to 10 of about 2,772,421 (294)

Diagnosis and Surgical Treatment of Drug-Resistant Epilepsy [PDF]

Brain Sciences, 2018
Despite appropriate trials of at least two antiepileptic drugs, about a third of patients with epilepsy remain drug resistant (intractable; refractory).
Chinekwu Anyanwu, Gholam K. Motamedi
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Benzodiazepine-resistant epilepsy: unraveling molecular mechanisms and developing multimodal therapeutic strategies

Frontiers in Neurology
Epilepsy is one of the most common nervous system diseases, which is characterized by recurrent seizures caused by abnormal neuronal discharges in the brain. Drug-resistant epilepsy (DRE) brings great challenges to clinical treatment.
Yanqiu Huang, Yangfan Zhang, Yi Liang
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Second‐hit DEPDC5 mutation is limited to dysmorphic neurons in cortical dysplasia type IIA

Annals of Clinical and Translational Neurology, 2019
Focal cortical dysplasia (FCD) causes drug‐resistant epilepsy and is associated with pathogenic variants in mTOR pathway genes. How germline variants cause these focal lesions is unclear, however a germline + somatic “2‐hit” model is hypothesized.
Wei Shern Lee, Sarah E. M. Stephenson, Katherine B. Howell, Kate Pope, Greta Gillies, Alison Wray, Wirginia Maixner, Simone A. Mandelstam, Samuel F. Berkovic, Ingrid E. Scheffer, Duncan MacGregor, Anthony Simon Harvey, Paul J. Lockhart, Richard J. Leventer   +13 more
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Ketogenic dietary therapy utilization in Kenya: A qualitative exploration of dietitian’s perceptions

Epilepsy & Behavior Reports
This study utilized a qualitative design to explore dietitians’ perceptions regarding Ketogenic Diet Therapy (KDT) for patients with drug-resistant epilepsy in Kenya. Dietitians from Kenya were selected and consented.
Pauline Samia, Violet Naanyu, J Helen Cross, Richard Idro, Paul Boon, Jo Wilmshurst, Stanley Luchters   +6 more
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Serum α-Synuclein in Pediatric Refractory Epilepsy: Correlation with Diagnosis and Clinical Severity

Medicina
Background and Objectives: Epilepsy is a common neurological disrupt that involves recurring seizures. α-Synuclein (α-Syn), one of the most abundant proteins in the nervous system, is implicated in both neurodegenerative conditions and epilepsy.
Aida M. S. Salem, Dalia Saber Morgan, Marwa O. Elgendy, Mohamed E. A. Abdelrahim, Noura Mostafa Mohamed Mostafa, Asmaa Saleh, Manar M. Abdel-Aziz, Asmaa K. Ramadan   +7 more
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Drug-resistant epilepsy treated with a vagus nerve stimulator – case report and literature review

Journal of Education, Health and Sport
The average incidence of epilepsy worldwide is estimated at 7.60 cases per 1,000 inhabitants, with an average annual incidence of 67.77 cases per 100,000 inhabitants. Epilepsy is one of the most common neurological diseases. However, it is not a disease
Michał Leśniewski, Dominika Brzuchacz, Patrycja Błaszczeć, Agata Miecznikowska, Natalia Siwak, Iwona Welian-Polus, Klaudia Szukała, Magdalena Chrościńska-Krawczyk   +7 more
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Beyond the seizures: Ketogenic Diets in the battle against drug-resistant epilepsy

Journal of Education, Health and Sport
Introduction: Epilepsy is a chronic, non-infectious and one of the most common neurological disease. About 70 million people worldwide suffer from it and these are patients of all ages. Despite the existence of many anticonvulsants and multiple lines of
Natalia Domańska, Małgorzata Bojarska, Julia Bogucka, Anna Brzyska, Michalina Kosowska, Halina Piecewicz-Szczęsna   +5 more
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Measurement of Irisin, Adiponectin, and Leptin Levels in Patients with Idiopathic Epilepsy

Bezmiâlem Science
Objective: Epilepsy is a common childhood neurological disorder in which neuroinflammatory and metabolic mechanisms may contribute to epileptogenesis.
Şeyma SÖNMEZ ŞAHİN, Türkan UYGUR ŞAHİN, Tuğçe YILDIZ, Zeynep Ebru ÇAKIN, Seher DURAN, Şahabettin SELEK, Dilara Füsun İÇAĞASIOĞLU, Akın İŞCAN   +7 more
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The thickness of the retinal nerve fiber layer, macula, and ganglion cell‐inner plexiform layer in people with drug‐resistant epilepsy

Epilepsia Open
Objective Using Optical coherence tomography (OCT), we evaluated the association between peripapillary retinal nerve fiber, macular thickness, macular ganglion cell‐inner plexiform layer, and drug resistance.
Yujie Chen, Weixi Xiong, Lu Lu, Xintong Wu, Le Cao, Jiani Chen, Yingfeng Xiao, Josemir W. Sander, Bo Wu, Dong Zhou   +9 more
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AFFECTIVE PROFILE OF PATIENTS WITH EPILEPSY: CLINICAL AND SOCIODEMOGRAPHIC INSIGHTS

Studia Universitatis Moldaviae: Stiinte ale Educatiei
Affective disorders, particularly depression and anxiety, are common comorbidities in individuals with epilepsy, significantly affecting quality of life, treatment adherence, and disease progression.
USM ADMIN
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