Results 31 to 40 of about 2,582,050 (300)

Premature mortality in refractory partial epilepsy: does surgical treatment make a difference? [PDF]

, 2010
Background: Epilepsy carries an increased risk of premature death. For some people with intractable focal epilepsy, surgery offers hope for a seizure-free life.
Scott, C.A., Sander, J.W., Sinha, S, Bell, G. S., de Tisi, J., Harkness, WF, McEvoy, A.W., Walker, M. C., Duncan, John S., Scott, CA, Smith, SJ, Bell, G.S., Stephani, C, McEvoy, A.W, Bell, G.S, Peacock, JL, Sander, Josemir W., Smith, S. J., McEvoy, AW, Walker, M.C., Harkness, W.F, Harkness, W.F., Tisi, J., Peacock, J. L., Scott, C.A, Duncan, JS, Smith, S.J, McEvoy, A. W., Sander, JW, Walker, MC, Duncan, J.S, Peacock, J.L, Stephani, C., Dunacan, S.J., Peacock, J.L., Tisi, J, Bell, GS, Walker, M.C, Stephani, Caspar, Scott, Catherine, Sinha, S., Harkness, W. F., Smith, S.J., de Tisi, J, Sander, J.W   +44 more
core   +1 more source

Surgical Management of Drug Resistant Epilepsy [PDF]

Al-Azhar International Medical Journal, 2020
Background: Epilepsy is a disease of the brain defined by any of the following conditions: At least 2 unprovoked (or reflex) seizures occurring more than 24 hours apart; One unprovoked (or reflex) seizure with relatively high recurrence risk (i.e., ≥60% (
Ahmed Gabr
doaj   +1 more source

Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy [PDF]

Brain, 2002
Epilepsy is resistant to drug treatment in about one-third of cases, but the mechanisms underlying this drug resistance are not understood. In cancer, drug resistance has been studied extensively. Amongst the various resistance mechanisms, overexpression of drug resistance proteins, such as multi-drug resistance gene-1 P-glycoprotein (MDR1) and ...
S M, Sisodiya, W-R, Lin, B N, Harding, M V, Squier, M, Thom   +4 more
openaire   +2 more sources

Surgical Management for drug-resistant Epilepsy in Medial Temporal Lobe Lesions (Al-Azhar experience) [PDF]

Al-Azhar International Medical Journal, 2022
Background: The most common cause of drug resistant epilepsy is the temporal lobe seizures especially that caused by medial temporal lobe epileptogenic lesions.
alaa ibrahim, mohamed rashad
doaj   +1 more source

The gut microbiome in drug‐resistant epilepsy [PDF]

Epilepsia Open, 2021
AbstractDrug‐resistant epileptic patients make up approximately one‐third of the global epilepsy population. The pathophysiology of drug resistance has not been fully elucidated; however, current evidence suggests intestinal dysbiosis, as a possible etiopathogenic factor.
Simela Chatzikonstantinou, Georgia Gioula, Vasilios K. Kimiskidis, Jack McKenna, Ioannis Mavroudis, Dimitrios Kazis   +5 more
openaire   +3 more sources

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles, Schwarz, J.M., Berfelo, M. W., M. Schwarz, Vles, J. S. H., Schwarz, M., Hulsman, J. A. R. J., A. Myint, Majoie, H. J. M., M.W. Berfelo, Hulsman, J.A.R.J., K. Rijkers, Myint, A., J.A.R.J. Hulsman, Rijkers, K., H.J.M. Majoie   +15 more
core   +1 more source

The Concept of Drug-Resistant Epileptogenic Zone

Frontiers in Neurology, 2019
Resective surgery is the most effective way to treat drug-resistant epilepsy. Despite extensive pre-surgical evaluation, only 30–70% patients would become seizure-free after surgery.
Chunbo Zhang, Patrick Kwan, Patrick Kwan
doaj   +1 more source

Health technology assessment report on the presurgical evaluation and surgical treatment of drug-resistant epilepsy

, 2013
PURPOSE: Epilepsy is a neurologic disorder with major social impact. Surgery is a valuable option in patients who are not responding to antiepileptic drugs.
C. o. Epilepsy, TINUPER, PAOLO, M. Scerrati, G. Colicchio, C. E. Marras, Commission on Epilepsy Surgery of the Italian League Against Epilepsy, M.P.Canevini, R. Guerrini, M. P. Canevini, G. Rubboli, R. Spreafico, G. LoRusso, P. Tinuper, L. Tassi   +13 more
core   +2 more sources

Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]

, 2014
Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core   +1 more source

Drug Resistant Epilepsy Among Patients Attended The Neurosciences Hospital

مجله كليه طب الكندي, 2019
Background: Drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom. Up to 30% of patients referred to clinics with a diagnosis of
Nael Husain Zaer
doaj   +1 more source