Results 1 to 10 of about 366,264 (296)

Alterations of apparent diffusion coefficient from ultra high b‐values in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy

Epilepsia Open
Objective Subcortical nuclei such as the thalamus and striatum have been shown to be related to seizure modulation and termination, especially in drug‐resistant epilepsy.
Guixian Tang, Hailing Zhou, Chunyuan Zeng, Yuanfang Jiang, Ying Li, Lu Hou, Kai Liao, Zhiqiang Tan, Huanhua Wu, Yongjin Tang, Yong Cheng, Xueying Ling, Qiang Guo, Hao Xu   +13 more
doaj   +1 more source

Deep brain stimulation in drug-resistant epilepsy: current status and future perspectives

Chinese Journal of Contemporary Neurology and Neurosurgery
Drug-resistant epilepsy remains a major challenge in management of epilepsy, with approximately half of patients being unsuitable candidates for resective surgery.
HU Tian-qi, XIE Hu-tao, ZHANG Jian-guo
doaj   +1 more source

Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course

Epilepsy and Behavior Case Reports, 2017
Septo-optic dysplasia (SOD) is a rare disorder associated with optic nerve hypoplasia, pituitary abnormalities and agenesis/dysgenesis of midline brain structures including the septum pellucidum and corpus callosum.
Mashael AlKhateeb, Richard McLachlan, Jorge Burneo, David Diosy, Seyed Mirsattari   +4 more
doaj   +1 more source

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy [PDF]

, 2017
Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role in drug-resistant epilepsy. The high-mobility group box 1 (HMGB1)/TLR4 axis
Alapirtti, Tiina, Antoine, Daniel, Brodie, Martin J., Frigerio, Federica, Jenkins, Rosalind E, Jorgensen, Andrea L, Marson, Anthony Guy, Park, Brian Kevin, Peltola, Jukka, Pirmohamed, Munir, Porcu, Luca, Ravizza, Teresa, Ricci, Emanuele, Sills, Graeme John, Thippeswamy, Thimmasettappa, Tse, Karen, Vezzani, Annamaria, Walker, Lauren Elizabeth   +17 more
core   +3 more sources

Galvanic skin response (GSR)/electrodermal/skin conductance biofeedback on epilepsy: a systematic review and meta-analysis [PDF]

, 2019
Objectives: Dynamic changes in psychophysiological arousal are directly expressed in the sympathetic innervation of the skin. This activity can be measured as tonic and phasic fluctuations in electrodermal activity [Galvanic Skin Response (GSR)/skin ...
Birbaumer, Casper, Cramer, Danielson, Englot, Kotwas, Kwan, Liberati, Lubar, Micoulaud-Franchi, Nagai, Nagai, Nagai, Nagai, Nagai, Nagai, Nagai, Neal, Raichle, Rockstroh, Scrimali, Speckmann, Sterman, Sterman, Tan, Venables, Voets   +26 more
core   +2 more sources

Integrating Artificial Intelligence with Real-time Intracranial EEG Monitoring to Automate Interictal Identification of Seizure Onset Zones in Focal Epilepsy

, 2018
An ability to map seizure-generating brain tissue, i.e., the seizure onset zone (SOZ), without recording actual seizures could reduce the duration of invasive EEG monitoring for patients with drug-resistant epilepsy.
Berry, Brent, Brinkmann, Benjamin, Cimbalnik, Jan, Iyer, Ravishankar, Kremen, Vaclav, Stead, Matt, Van Gompel, Jamie, Varatharajah, Yogatheesan, Worrell, Gregory   +8 more
core   +1 more source

2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs [PDF]

, 2016
This report represents a scientific and working clinical consensus statement on seizure management in dogs based on current literature and clinical expertise.
Bunch SE, Bunch SE, Cheuk DK, Cunningham JG, Dayrell‐Hart B, Durkes TE, Dyer KR, E.E. Patterson, Farnbach GC, Farnbach GC, Forrester SD, Frey HH, Gaskill CL, Gaskill CL, H.A. Volk, Jacobs G, Jennings PB, K. Muñana, Kantrowitz LB, M. Berendt, M. Podell, March PA, Masuda Y, Nichols ES, Patterson E, Pearce L, Pedersoli WM, Perrucca E, Poffenbarger EM, Ravis WR, S.R. Platt, Schwartz‐Porsche D, Schwartz‐Porsche D, Steinberg M, Thurman GD, Trepanier LA, Trepanier LA, W. Löscher   +37 more
core   +2 more sources

Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy

The Journal of Clinical Investigation
The histopathological neurons in the brain tissue of drug-resistant epilepsy exhibit aberrant cytoarchitecture and imbalanced synaptic circuit function.
Qianqian Ge, Jiachao Yang, Fei Huang, Xinyue Dai, Chao Chen, Jingxin Guo, Mi Wang, Mengyue Zhu, Yijie Shao, Yuxian Xia, Yu Zhou, Jieqiao Peng, Suixin Deng, Jiachen Shi, Yiqi Hu, Huiying Zhang, Yi Wang, Xiaoqun Wang, Xiao-Ming Li, Zhong Chen, Yousheng Shu, Jun-Ming Zhu, Jianmin Zhang, Ying Shen, Shumin Duan, Shengjin Xu, Li Shen, Jiadong Chen   +27 more
doaj   +1 more source

Diagnosis and Surgical Treatment of Drug-Resistant Epilepsy

Brain Sciences, 2018
Despite appropriate trials of at least two antiepileptic drugs, about a third of patients with epilepsy remain drug resistant (intractable; refractory).
Chinekwu Anyanwu, Gholam K. Motamedi
doaj   +1 more source

A Novel Long-term, Multi-Channel and Non-invasive Electrophysiology Platform for Zebrafish. [PDF]

, 2016
Zebrafish are a popular vertebrate model for human neurological disorders and drug discovery. Although fecundity, breeding convenience, genetic homology and optical transparency have been key advantages, laborious and invasive procedures are required for
Baraban, Scott C, Hong, SoonGweon, Lee, Luke P, Lee, Philip   +3 more
core   +1 more source