Results 21 to 30 of about 366,264 (296)

Incidence and Prevalence of Drug-Resistant Epilepsy

Neurology, 2021
Objective To evaluate the incidence and prevalence of drug-resistant epilepsy (DRE) as well as its predictors and correlates, we conducted a systematic review and meta-analysis of observational studies.
B. Sultana, Marie-Andrée Panzini, Ariane Veilleux Carpentier, J. Comtois, B. Rioux, G. Gore, P. Bauer, C. Kwon, N. Jetté, C. Josephson, M. Keezer   +10 more
semanticscholar   +1 more source

Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments

Cells, 2023
In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into the market for the treatment of epilepsy using well-established preclinical seizure and epilepsy models. Despite this success, approximately 20–30% of patients with
Katarzyna Socała, Piotr Wla´z, A. Dityatev, Naweed I. Syed, A. E. Kalyuzhny, W. Löscher, H. White   +6 more
semanticscholar   +1 more source

Twenty‐five years of epilepsy surgery at a Central European comprehensive epilepsy center—Trends in intervention delay and outcomes

Epilepsia Open, 2023
Objective We analyzed trends in patients' characteristics, outcomes, and waiting times over the last 25 years at our epilepsy surgery center situated in Central Europe to highlight possible areas of improvement in our care for patients with drug ...
Vít Všianský, Milan Brázdil, Ivan Rektor, Irena Doležalová, Jitka Kočvarová, Ondřej Strýček, Jan Hemza, Jan Chrastina, Eva Brichtová, Ondřej Horák, Patrícia Mužlayová, Markéta Hermanová, Michal Hendrych, Martin Pail   +13 more
doaj   +1 more source

Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry

Neurology, 2023
Background and Objectives The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for
J. Peltola, A. Colon, J. Pimentel, V. Coenen, A. Gil-Nagel, A. Gonçalves Ferreira, K. Lehtimäki, Philippe Ryvlin, Rodney S Taylor, L. Ackermans, Jacqueline Ardesch, C. Bentes, Magdalena Bosak, J. Burneo, C. Chamadoira, C. Elger, L. Erőss, Dániel Fabó, Howard J. Faulkner, J. Gawłowicz, A. Gharabaghi, M. Iacoangeli, J. Janszky, Soila Järvenpää, E. Kaufmann, K. Kho, E. Kumlien, H. Laufs, C. Lettieri, P. Linhares, S. Noachtar, A. Parrent, E. Pataraia, N. Patel, A. Peralta, Attila Rácz, A. R. Campos, R. Rego, R. Ricciuti, S. Rona, R. Rouhl, A. Schulze-Bonhage, R. Schuurman, M. Sprengers, A. Sufianov, Y. Temel, T. Theys, W. van Paesschen, D. Van Roost, R. Vaz, K. Vonck, L. Wagner, J. Zwemmer, A. Abouihia, Thomas C. Brionne, F. Gielen, P. Boon   +56 more
semanticscholar   +1 more source

Introduction to the special issue “Redesigning the hypotheses for drug‐resistant epilepsy”

Epilepsia Open, 2022
Drug‐resistant epilepsy represents an important neurological condition. Its prevalence is not modified in spite of the different hypotheses established to understand the mechanisms involved.
Luisa Rocha
doaj   +1 more source

Knowledge and awareness toward surgical treatment of epilepsy among medical students at Umm Al-Qura University

SAGE Open Medicine, 2022
Objective: This study aims to evaluate knowledge and awareness toward surgical treatment of epilepsy among medical students at Umm Al-Qura University.
Rami Algahtani, Qamar ALhothaly, Raghd Alabdullah, Omniyh Fatani, Asmaa Alsaeigh, Amal Alamri, Abdullah Tawakul, Jihad Muglan   +7 more
doaj   +1 more source

Risk factors for drug-resistant epilepsy in adult patients.

Medicina clínica (Ed. impresa), 2023
INTRODUCTION Drug-resistant epilepsy occurs in about 30% of epilepsy patients. It has been suggested that etiology or seizure type would increase the risk of pharmacoresistance.
Ignacio Lagger, Eliana Garino, O. Martínez, Eduardo Knorre, G. Ernst, A. Burgueño   +5 more
semanticscholar   +1 more source

Drug resistance in epilepsy [PDF]

Epilepsia, 2010
SummaryDrug resistance remains one of the major challenges in epilepsy therapy. Identification of factors that contribute to therapeutic failure is crucial for future development of novel drugs and therapeutic strategies for difficult‐to treat epilepsies. For an expanded treatment of this topic see Jasper’s basic mechanisms of the epilepsies.
Jan Gorter, Heidrun Potschka
openaire   +3 more sources

The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients [PDF]

, 2020
Temporal lobe epilepsy (TLE) is the most common type of partial epilepsy referred for surgery due to antiepileptic drug (AED) resistance. A common molecular target for many of these drugs is the voltage-gated sodium channel (VGSC).
Falciani, Francesco, Princivalle, Alessandra, Sheilabi, Mariam A., Sims, Edward J., Takeshita, Louise Y.   +4 more
core   +1 more source

Relationship between Neuroglial Apoptosis and Neuroinflammation in the Epileptic Focus of the Brain and in the Blood of Patients with Drug-Resistant Epilepsy

International Journal of Molecular Sciences, 2022
Neuroglial apoptosis and neuroinflammation play an important role in epileptogenesis. The aim of this study is to evaluate neuronal and glial apoptosis in association with neuroinflammation in brain epileptic focus and inflammatory changes in blood in ...
T. Sokolova, Yulia M Zabrodskaya, A. Litovchenko, N. M. Paramonova, V. Kasumov, S. Kravtsova, E. Skiteva, D. Sitovskaya, E. Bazhanova   +8 more
semanticscholar   +1 more source