Results 21 to 30 of about 39,256 (202)

How do children with drug-resistant epilepsy sleep? A clinical and video-PSG study

, 2021
Aim: The aim of this study was to assess sleep architecture and sleep problems among three homogenous groups of children including children with drug-resistant focal epilepsy, children with newly diagnosed, drug-naive focal epilepsy, and healthy children
Arhan, Ebru, Koç Uçar, Habibe, Serdaroğlu, Ayşe, Aydın, Kürşad, Lüleci Hirfano?lu, Tu?ba   +4 more
core   +1 more source

The Association Between STX1B Polymorphisms and Treatment Response in Patients With Epilepsy

Frontiers in Pharmacology, 2021
Background: Epilepsy is a debilitating brain disease with complex inheritance and frequent treatment resistance. However, the role of STX1B single nucleotide polymorphisms (SNPs) in epilepsy treatment remains unknown.Objective: This study aimed to ...
Shitao Wang, Liang Zhou, Chenglu He, Dan Wang, Xuemei Cai, Yanying Yu, Liling Chen, Di Lu, Ligong Bian, Sunbing Du, Qian Wu, Yanbing Han   +11 more
doaj   +1 more source

Cannabis use patterns in drug-resistant and pharmacoresponsive epilepsy: Single tertiary referral center survey investigation.

PLoS ONE, 2023
This study sought to identify differences in cannabis use and perceptions about cannabis in mitigating seizure-related symptoms in patients with epilepsy, and to evaluate differences in these patterns between drug-resistant versus pharmacoresponsive ...
Danielle McDermott, Marielle L Darwin, Kirsten Fetrow, Ian Coulter, Kristal Biesecker, John A Thompson   +5 more
doaj   +1 more source

Pathophysiology of drug-resistant canine epilepsy

The Veterinary Journal, 2023
Drug resistance continues to be a major clinical problem in the therapeutic management of canine epilepsies with substantial implications for quality of life and survival times. Experimental and clinical data from human medicine provided evidence for relevant contributions of intrinsic severity of the disease as well as alterations in pharmacokinetics ...
Heidrun, Potschka, Andrea, Fischer, Wolfgang, Löscher, Holger A, Volk   +3 more
openaire   +2 more sources

Premature mortality in refractory partial epilepsy: does surgical treatment make a difference? [PDF]

, 2010
Background: Epilepsy carries an increased risk of premature death. For some people with intractable focal epilepsy, surgery offers hope for a seizure-free life.
Scott, C.A., Sander, J.W., Sinha, S, Bell, G. S., de Tisi, J., Harkness, WF, McEvoy, A.W., Walker, M. C., Duncan, John S., Scott, CA, Smith, SJ, Bell, G.S., Stephani, C, McEvoy, A.W, Bell, G.S, Peacock, JL, Sander, Josemir W., Smith, S. J., McEvoy, AW, Walker, M.C., Harkness, W.F, Harkness, W.F., Tisi, J., Peacock, J. L., Scott, C.A, Duncan, JS, Smith, S.J, McEvoy, A. W., Sander, JW, Walker, MC, Duncan, J.S, Peacock, J.L, Stephani, C., Dunacan, S.J., Peacock, J.L., Tisi, J, Bell, GS, Walker, M.C, Stephani, Caspar, Scott, Catherine, Sinha, S., Harkness, W. F., Smith, S.J., de Tisi, J, Sander, J.W   +44 more
core   +1 more source

Predictors of referral for long‐term EEG monitoring for Medicare beneficiaries with drug‐resistant epilepsy

Epilepsia Open, 2023
Objective For people with drug‐resistant epilepsy, the use of epilepsy surgery is low despite favorable odds of seizure freedom. To better understand surgery utilization, we explored factors associated with inpatient long‐term EEG monitoring (LTM), the ...
Chloe E. Hill, Chun Chieh Lin, Samuel W. Terman, Darin Zahuranec, Jack M. Parent, Lesli E. Skolarus, James F. Burke   +6 more
doaj   +1 more source

Analysis of heart rate variability and risk factors for SUDEP in patients with drug-resistant epilepsy

, 2021
Background: Cardiac problems have been suggested as causes of sudden unexpected death in epilepsy (SUDEP). Our aim was to investigate possible associations of cardiac autonomic functions based on heart rate variability (HRV) parameters with risk factors ...
Serbest, Nail Guven, Bebek, Nerses, Baysal-Kirac, Leyla, Gokyigit, Aysen, Sahin, Erdi, Gurses, Candan, Bilge, Ahmet Kaya, Baykan, BETÜL, Dede, Hava Ozlem   +8 more
core   +1 more source

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles, Schwarz, J.M., Berfelo, M. W., M. Schwarz, Vles, J. S. H., Schwarz, M., Hulsman, J. A. R. J., A. Myint, Majoie, H. J. M., M.W. Berfelo, Hulsman, J.A.R.J., K. Rijkers, Myint, A., J.A.R.J. Hulsman, Rijkers, K., H.J.M. Majoie   +15 more
core   +1 more source

Surgical Management of Drug Resistant Epilepsy [PDF]

Al-Azhar International Medical Journal, 2020
Background: Epilepsy is a disease of the brain defined by any of the following conditions: At least 2 unprovoked (or reflex) seizures occurring more than 24 hours apart; One unprovoked (or reflex) seizure with relatively high recurrence risk (i.e., ≥60% (
Ahmed Gabr
doaj   +1 more source

Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy [PDF]

Brain, 2002
Epilepsy is resistant to drug treatment in about one-third of cases, but the mechanisms underlying this drug resistance are not understood. In cancer, drug resistance has been studied extensively. Amongst the various resistance mechanisms, overexpression of drug resistance proteins, such as multi-drug resistance gene-1 P-glycoprotein (MDR1) and ...
S M, Sisodiya, W-R, Lin, B N, Harding, M V, Squier, M, Thom   +4 more
openaire   +2 more sources