Results 11 to 20 of about 33,337 (262)

The gut microbiome in drug‐resistant epilepsy [PDF]

Epilepsia Open, 2021
AbstractDrug‐resistant epileptic patients make up approximately one‐third of the global epilepsy population. The pathophysiology of drug resistance has not been fully elucidated; however, current evidence suggests intestinal dysbiosis, as a possible etiopathogenic factor.
Simela Chatzikonstantinou, Georgia Gioula, Vasilios K. Kimiskidis, Jack McKenna, Ioannis Mavroudis, Dimitrios Kazis   +5 more
openaire   +3 more sources

BEHAVIOURAL PARTICULARITIES OF PATIENTS WITH DRUG-RESISTANT EPILEPSY: A COMPARATIVE STUDY [PDF]

Psihologie
This study examines the behavioral particularities of individuals with epilepsy, focusing on aggression, hostility, and shyness in patients with drug-resistant epilepsy compared to those with well-controlled epilepsy.
Natalia DOȚEN
doaj   +1 more source

The Association Between STX1B Polymorphisms and Treatment Response in Patients With Epilepsy

Frontiers in Pharmacology, 2021
Background: Epilepsy is a debilitating brain disease with complex inheritance and frequent treatment resistance. However, the role of STX1B single nucleotide polymorphisms (SNPs) in epilepsy treatment remains unknown.Objective: This study aimed to ...
Shitao Wang, Liang Zhou, Chenglu He, Dan Wang, Xuemei Cai, Yanying Yu, Liling Chen, Di Lu, Ligong Bian, Sunbing Du, Qian Wu, Yanbing Han   +11 more
doaj   +1 more source

Cannabis use patterns in drug-resistant and pharmacoresponsive epilepsy: Single tertiary referral center survey investigation.

PLoS ONE, 2023
This study sought to identify differences in cannabis use and perceptions about cannabis in mitigating seizure-related symptoms in patients with epilepsy, and to evaluate differences in these patterns between drug-resistant versus pharmacoresponsive ...
Danielle McDermott, Marielle L Darwin, Kirsten Fetrow, Ian Coulter, Kristal Biesecker, John A Thompson   +5 more
doaj   +1 more source

Pathophysiology of drug-resistant canine epilepsy

The Veterinary Journal, 2023
Drug resistance continues to be a major clinical problem in the therapeutic management of canine epilepsies with substantial implications for quality of life and survival times. Experimental and clinical data from human medicine provided evidence for relevant contributions of intrinsic severity of the disease as well as alterations in pharmacokinetics ...
Heidrun, Potschka, Andrea, Fischer, Wolfgang, Löscher, Holger A, Volk   +3 more
openaire   +2 more sources

Predictors of referral for long‐term EEG monitoring for Medicare beneficiaries with drug‐resistant epilepsy

Epilepsia Open, 2023
Objective For people with drug‐resistant epilepsy, the use of epilepsy surgery is low despite favorable odds of seizure freedom. To better understand surgery utilization, we explored factors associated with inpatient long‐term EEG monitoring (LTM), the ...
Chloe E. Hill, Chun Chieh Lin, Samuel W. Terman, Darin Zahuranec, Jack M. Parent, Lesli E. Skolarus, James F. Burke   +6 more
doaj   +1 more source

Epidemiology of drug resistant epilepsy in adults

Бюллетень сибирской медицины, 2018
This review examines the epidemiology of drug resistant epilepsy in adults in Russia and abroad. References were taken from Russian and foreign databases for the period from 2010–2017. Only full-text publications (66) were included in this review.
E. A. Narodova, N. A. Shnayder, S. V. Prokopenko, V. V. Narodova, A. A. Narodov, D. V. Dmitrenko   +5 more
doaj   +1 more source

Surgical Management of Drug Resistant Epilepsy [PDF]

Al-Azhar International Medical Journal, 2020
Background: Epilepsy is a disease of the brain defined by any of the following conditions: At least 2 unprovoked (or reflex) seizures occurring more than 24 hours apart; One unprovoked (or reflex) seizure with relatively high recurrence risk (i.e., ≥60% (
Ahmed Gabr
doaj   +1 more source

Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy [PDF]

Brain, 2002
Epilepsy is resistant to drug treatment in about one-third of cases, but the mechanisms underlying this drug resistance are not understood. In cancer, drug resistance has been studied extensively. Amongst the various resistance mechanisms, overexpression of drug resistance proteins, such as multi-drug resistance gene-1 P-glycoprotein (MDR1) and ...
S M, Sisodiya, W-R, Lin, B N, Harding, M V, Squier, M, Thom   +4 more
openaire   +2 more sources

The Concept of Drug-Resistant Epileptogenic Zone

Frontiers in Neurology, 2019
Resective surgery is the most effective way to treat drug-resistant epilepsy. Despite extensive pre-surgical evaluation, only 30–70% patients would become seizure-free after surgery.
Chunbo Zhang, Patrick Kwan, Patrick Kwan
doaj   +1 more source