Results 41 to 50 of about 2,772,421 (294)

Surgical Management for drug-resistant Epilepsy in Medial Temporal Lobe Lesions (Al-Azhar experience) [PDF]

open access: yesAl-Azhar International Medical Journal, 2022
Background: The most common cause of drug resistant epilepsy is the temporal lobe seizures especially that caused by medial temporal lobe epileptogenic lesions.
alaa ibrahim, mohamed rashad
doaj   +1 more source

Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults [PDF]

open access: yes, 2013
Marco MulaDivision of Neurology, Trinity Hospital, Borgomanero, ItalyAbstract: Epilepsy is one of the most common neurologic disorders, affecting about 50 million people around the world.
Mula M, Mula, M
core   +1 more source

Current Principles in the Management of Drug-Resistant Epilepsy [PDF]

open access: yes, 2022
Drug-resistant epilepsy is associated with poor health outcomes and increased economic burden. In the last three decades, various new antiseizure medications have been developed, but the proportion of people with drug-resistant epilepsy remains ...
Shlobin, Nathan, Sander, Josemir
core   +1 more source

Drug-resistant epilepsy associated with cortical dysplasias [PDF]

open access: yes, 2013
Epilepsy associated with malformations of the cerebral cortex is reported in the literature to account for up to 25% of the total cases of symptomatic epilepsies. It is characterized by the most severe course and often induces drug-resistance in seizures.
I. E. Poverennova, T. V. Kuznetsova
core   +1 more source

Drug Resistant Epilepsy Among Patients Attended The Neurosciences Hospital

open access: yesمجله كليه طب الكندي, 2019
Background: Drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom. Up to 30% of patients referred to clinics with a diagnosis of
Nael Husain Zaer
doaj   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei   +4 more
wiley   +1 more source

Surgery in Epilepsy – How Advances in Human Neurology Can Benefit Veterinary Patients

open access: yesVeterinary Evidence, 2016
This article reports the evidence behind pre-surgical evaluation and epilepsy surgery in human patients with drug-resistant idiopathic epilepsy and how this could potentially form the basis for the treatment of canine drug-resistant epilepsy in the ...
Marios Charalambous
doaj   +1 more source

MicroRNA-221-3p Suppresses the Microglia Activation and Seizures by Inhibiting of HIF-1α in Valproic Acid-Resistant Epilepsy

open access: yesFrontiers in Pharmacology, 2021
One-third of patients with epilepsy suffer from drug-resistant epilepsy (DRE). Valproic acid (VPA) is a classic anticonvulsant drug, and its resistance is a crucial predictor of DRE, but the pathogenesis remain unknown.
Meng Fu   +7 more
doaj   +1 more source

Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]

open access: yes, 2014
Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core   +1 more source

Clinical predictors of drug-resistant epilepsy in children

open access: yes, 2021
Background/aim: In up to 20% of epilepsy patients, seizures may not be controlled despite the use of antiepileptic drugs, either alone or in combination. These individuals are considered to have drug-resistant epilepsy. Drug-resistant epilepsy is usually
YİŞ, ULUÇ   +10 more
core   +1 more source

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