Results 51 to 60 of about 74,202 (303)
The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs [PDF]
, 2019 Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary.
Dag, Ramazan +4 more
core +1 more source
Frontiers in NeurologyAn increasing number of gene mutations associated with epilepsy have been identified, some linked to gray matter heterotopia—a common cause of drug-resistant epilepsy.
Zijian Li +5 more
doaj +1 more source
Cost-Effectiveness of Advanced Imaging Technologies in the Presurgical Workup of Epilepsy. [PDF]
, 2020 The cost-effectiveness and benefit of many diagnostic tests used in the presurgical evaluation for persons with epilepsy is for the most part uncertain as is their influence on decision-making.
Chang, Edward F +2 more
core
Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy [PDF]
Brain, 2002 Epilepsy is resistant to drug treatment in about one-third of cases, but the mechanisms underlying this drug resistance are not understood. In cancer, drug resistance has been studied extensively. Amongst the various resistance mechanisms, overexpression of drug resistance proteins, such as multi-drug resistance gene-1 P-glycoprotein (MDR1) and ...
S M, Sisodiya +4 more
openaire +2 more sources
Evaluation of Risk Factors for Epilepsy in Pediatric Patients with Cerebral Palsy
Brain Sciences, 2020 Cerebral palsy (CP) is a set of etiologically diverse symptoms that change with the child’s age. It is one of the most frequent causes of motor disability in children. CP occurs at a frequency of 1.5 to 3.0 per 1000 live-born children.
Małgorzata Sadowska +2 more
doaj +1 more source
Drug-Resistant Juvenile Myoclonic Epilepsy: Misdiagnosis of Progressive Myoclonus Epilepsy [PDF]
Frontiers in Neurology, 2019 Juvenile myoclonic epilepsy (JME) is a common epilepsy syndrome characterized by bilateral myoclonic and tonic-clonic seizures typically starting in adolescence and responding well to medication. Misdiagnosis of a more severe progressive myoclonus epilepsy (PME) as JME has been suggested as a cause of drug-resistance.
Sarah Martin +23 more
openaire +5 more sources
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]
, 2018 The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique +8 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source
Clinical diagnostic features and surgical outcomes of mesial temporal lobe epilepsy
Вестник хирургии имени И.И. Грекова, 2023 Despite certain successes in the treatment of epilepsy, primarily associated with the active development of pharmacology, in 30% of cases, there is a resistant course, especially focal forms of temporal lobe epilepsy.
O. P. Subbotina +2 more
doaj +1 more source