Results 201 to 210 of about 980 (274)
MEK Inhibitor Associated Airway Injury in an Infant With Noonan Syndrome: A Case Report
The Laryngoscope, EarlyView.An infant with Noonan syndrome treated with trametinib developed extensive mucosal sloughing of the upper and lower airway, followed by severe supraglottic scarring. Clinicians should consider airway toxicity as a potential adverse effect of MEK inhibitor therapy.
Veronica Drozdowski‐Nuccio +4 more
wiley +1 more source
Outcomes of Recurrent Laryngeal Nerve Reinnervation for Pediatric Unilateral Vocal Fold Paralysis
The Laryngoscope, EarlyView.The objective of this study was to describe voice outcomes from the largest single‐center, single‐surgeon experience with recurrent laryngeal nerve reinnervation for pediatric unilateral vocal fold paralysis. In 102 patients who underwent reinnervation, we demonstrate that reinnervation is an effective and durable intervention for treatment of ...
Theodore A. Gobillot +2 more
wiley +1 more source
Effects of Intubation Duration on Trachea: A Histopathological Study
The Laryngoscope, EarlyView.This study evaluated the histopathological effects of prolonged endotracheal intubation on the human trachea using biopsy specimens obtained during tracheotomy. Prolonged intubation was associated with progressive inflammatory and structural changes, with tracheal dilatation and perichondritis increasing significantly after 14 days.
Osman Kilic +6 more
wiley +1 more source
Effect of Notch1 on Vocal Fold Re‐Epithelization After Acute Injury
The Laryngoscope, EarlyView.Conditional deletion of Notch1 in Lrig1‐expressing vocal fold epithelial cells impaired re‐epithelialization following naphthalene injury, resulting in sustained basal cell proliferation, abnormal epithelial differentiation, and prolonged inflammatory cell infiltration.
Jie Cai +2 more
wiley +1 more source
Vocal Fold Atrophy in Patients With Alzheimer's Disease and Related Dementias
The Laryngoscope, EarlyView.This is the first study to quantify vocal fold atrophy in patients with Alzheimer's disease and related dementias (AD/ADRD) using endoscopic imaging. Compared with age‐matched controls, AD/ADRD patients showed significantly greater vocal fold bowing and reduced mucosal wave amplitude, while normalized glottal gap area did not differ.
Byron Kim +5 more
wiley +1 more source
A Scoping Review of Laryngeal Edema Rating Scales for Extubated Acute Respiratory Failure Survivors
The Laryngoscope, EarlyView.This scoping review identified existing laryngeal edema rating scales and evaluated whether any are adequately designed for post‐extubation acute respiratory failure (ARF) survivors. Across 35 included studies, most used subjective binary classifications and only the RTOG and Patterson Edema scales had operational definitions and reliability/validity ...
Lalita Sabat +4 more
wiley +1 more source
Depth of Invasion Predicts Vocal Fold Motility and Muscle Invasion in Glottic Carcinoma
The Laryngoscope, EarlyView.To determine whether depth of invasion (DOI) provides an objective surrogate for vocal fold motility and vocal muscle invasion in glottic squamous cell carcinoma. Methods and Results: In derivation and external validation cohorts, radiologic DOI strongly correlated with pathologic DOI and accurately predicted altered vocal fold motility and muscle ...
Elisa Bellini +22 more
wiley +1 more source
Association of Glucagon‐Like Peptide—1 Receptor Analogues and Laryngeal Symptoms in Obese Adults
The Laryngoscope, EarlyView.Table 1 succinctly quantifies the time‑dependent association between GLP‑1RA/GIP therapy and laryngeal symptoms, demonstrating modest but statistically robust increases in outcomes such as cough and voice/resonance disorders by 6 months. It provides clinically actionable absolute risks, odds ratios, and hazard ratios that can directly inform counseling,
Priyanka Shah +4 more
wiley +1 more source