Results 51 to 60 of about 75,931 (290)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Vocation As Curse [PDF]

open access: yes, 1999
This Essay argues that while legal work as a vocation may have positive effects for society as a whole, as well as overall benefits for the legal profession, vocation could very well hurt the lawyer called to take up such a vocation. A vocation is not
Giba-Matthews, ofm, F.
core   +1 more source

The associational pathway of emotional exhaustion among college students under perception of involution: the mediation model of self-compassion and psychological resilience

open access: yesFrontiers in Psychology
BackgroundThis study focuses on university students and examines the relationship between perception of involution and emotional exhaustion, with psychological resilience and self-compassion included as mediating variables.MethodsA cross-sectional design
Si Li, Wenyan Chen
doaj   +1 more source

Un homme pressé

open access: yesLa Nouvelle Revue du Travail, 2021
The article uses a methodological and analytical approach to biographical interviews to present the journey of a law student who comes from a privileged background and has invested, alongside his studies, in an entrepreneurial project.
Olivia Chambard
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Career Strategies for Higher Education Teachers

open access: yesСоциологическая наука и социальная практика, 2022
The article analyses autobiographical essays on key career stages and typical career paths written by Russian university teachers. Motives and attitudes influencing their decisions whether to continue or finish their careers are identified.
Galina Z. Efimova
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Multi-modal and multi-agent reinforcement learning framework for urban traffic flow prediction and signal control optimization

open access: yesScientific Reports
The rapid urbanization of cities has exacerbated traffic congestion, resulting in significant environmental impacts, including elevated greenhouse gas emissions and deteriorating air quality.
Ruokun Wang   +4 more
doaj   +1 more source

“You’re Not a Real Contemporary Dancer.” Discrepancy and Appropriation of the Artists’ Status by Dancers from a Working Class Background

open access: yesSwiss Journal of Sociology, 2017
This article draws on a long-term ethnographical survey. It aims to discuss the social conditions of possibility in the artistic calling of contemporary dancers from working class backgrounds.
Sorignet Pierre-Emmanuel
doaj   +1 more source

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