Results 51 to 60 of about 75,980 (289)

The Vocation of a Doctor [PDF]

open access: yesThe Linacre Quarterly, 2012
Doctors are called to a life of compassionate service to human beings invested with intrinsic dignity. This essay is adapted from the commencement address that Dr. Landry delivered at the St. Louis University School of Medicine on July 18, 2011.
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Vocation

open access: yes, 2008
This chapter examines the concept of religious vocation. In Christian history, vocation has become bound up with the category of work in three different ways. The chapter explains these three ways.
John G. Stackhouse
core   +1 more source

Multi-modal and multi-agent reinforcement learning framework for urban traffic flow prediction and signal control optimization

open access: yesScientific Reports
The rapid urbanization of cities has exacerbated traffic congestion, resulting in significant environmental impacts, including elevated greenhouse gas emissions and deteriorating air quality.
Ruokun Wang   +4 more
doaj   +1 more source

“You’re Not a Real Contemporary Dancer.” Discrepancy and Appropriation of the Artists’ Status by Dancers from a Working Class Background

open access: yesSwiss Journal of Sociology, 2017
This article draws on a long-term ethnographical survey. It aims to discuss the social conditions of possibility in the artistic calling of contemporary dancers from working class backgrounds.
Sorignet Pierre-Emmanuel
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

La vocation du Prince

open access: yes, 2013
Qu’est-ce que la vocation à l’aube de l’époque moderne ? Issu du verbe vocare, le substantif latin vocatio signifie « appel ». Aussi la vocation a-t-elle pour sens premier l’appel à accomplir la volonté divine.
Edouard, Sylvène   +4 more
core   +1 more source

La correspondance de Jacques Rivière et Alain-Fournier : une aventure de la lecture

open access: yesItinéraires, 2010
Through a precise study of the letters that Jacques Rivière and Alain-Fournier wrote to each other between 1904 and 1909, when they were young men, the article uncovers a form of existential event in the very act of reading.
Julie Aucagne
doaj   +1 more source

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