Results 181 to 190 of about 33,837 (314)

Tannic Acid Mitigates Monosodium Glutamate‐Induced Cortical Damage by Modulating Synaptic and Calcium‐Related Gene and Protein Expression

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Neurotoxicity induced by excessive glutamatergic signaling is associated with synaptic dysfunction, calcium imbalance, and oxidative stress, which are key molecular events implicated in several neurodegenerative conditions. Monosodium glutamate (MSG), a common flavor enhancer, may exert neurotoxic effects, particularly on synaptic integrity ...
Medine Sibel Karagac   +2 more
wiley   +1 more source

A pilot study of the phase-elective curriculum in Maury High School in Norfolk, Virginia, and implications for vocational educational programs in the commonwealth

open access: yes, 1976
The purpose of this study was to determine change in enrollment and completions in vocational programs in a phase-elective, non-graded, flexibly scheduled curriculum in Maury High School, Norfolk, Virginia, through comparison with the enrollment and ...
Wilson, Shirley Burgess
core  

Protective Role of Polydatin Against Vancomycin‐Induced Lung Toxicity via Oxidative Stress, Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Ferroptosis Pathways

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate whether polydatin (Poly) could eliminate the harmful effects of vancomycin (VCM) on the lungs of rats. Rats were administered VCM (200 mg/kg) and Poly (50 mg/kg), both separately and in combination, for a duration of 7 days.
Serpil Aygörmez   +6 more
wiley   +1 more source

Epirubicin Alters Pancreatic Autophagy and Insulin Synthesis Through a Zinc‐Dependent Mechanism

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Epirubicin (EPI) can cause metabolic side effects, including chemotherapy‐related diabetes, partly through oxidative stress that disrupts zinc (Zn) homeostasis and impairs autophagy. This study investigated the effects of EPI on Zn regulation and autophagy in the pancreas, as well as the modulatory role of N‐acetylcysteine (NAC). Rats received
Ebru Afşar, Işıl Eranıl
wiley   +1 more source

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol   +4 more
wiley   +1 more source

Trajectories of child emotional and behavioural difficulties before and during the COVID‐19 pandemic in a longitudinal UK cohort

open access: yesJCPP Advances, EarlyView.
Abstract Background There are substantial age‐related changes in emotional and behavioural problems over childhood. In order to establish the impact of the Covid‐19 pandemic on child emotional and behavioural problems, longitudinal designs which take into account age‐related trends are needed.
Nicky Wright   +13 more
wiley   +1 more source

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