Results 31 to 40 of about 33,379 (263)

Experimental Identification of the Void Fraction in a Large Hydrodynamic Offset Halves Bearing

open access: yesLubricants
A common approach to optimising hydrodynamic journal bearings for power loss is to reduce the lubricant supply and direct the oil to specific bearing areas where it is needed to guarantee safe operation.
Alexander Engels   +6 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Void-Fraction Measurements in Cavitating Mercury [PDF]

open access: yesNuclear Applications, 1965
Gamma-ray densitometer technique for precise measurement of local or mean density in axially symmetric two phase flow with attention to cavitating mercury in ...
Frederick G. Hammitt   +4 more
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Experimental Study on Interfacial Area Transport of Two-Phase Flow under Vibration Conditions

open access: yesScience and Technology of Nuclear Installations, 2017
An experimental study on air-water two-phase flow under vibration condition has been conducted using double-sensor conductivity probe. The test section is an annular geometry with hydraulic diameter of 19.1 mm. The vibration frequency ranges from 0.47 Hz
Xiu Xiao   +5 more
doaj   +1 more source

Experimental study and analysis of design parameters for analysis of fluidelastic instability for steam generator tubing

open access: yesNuclear Engineering and Technology, 2023
In this paper, the evaluation method of fluidelastic instability (FEI) of newly designed steam generator tubing in pressurized water reactor (PWR) nuclear power plants is discussed.
Xiong Guangming   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Void fraction measurement in cryogenic flows. Part I: Design and validation of a void fraction capacitive sensor

open access: yesCryogenics, 2018
Abstract This manuscript presents the design of a capacitive void fraction sensor for cryogenic LN2 two phase flows and its validation at room conditions. The capacitive void fraction sensor is first designed by means of Electric Field Analysis (EFA) simulations taking into account specific technical constraints coming from the test section in which ...
Sakamoto, Yuki   +5 more
openaire   +1 more source

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