Results 61 to 70 of about 50,714 (300)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Void Hierarchy in the Northern Local Void [PDF]

Symposium - International Astronomical Union, 1999
Empirical studies of the Large–Scale Structure in the nearby Universe come in two complementary modes, namely the investigation of either the distribution of luminous matter or voids: (i) The description of the galaxy and cluster distribution employs correlation functions, clustering analysis, topological methods, et cetera.
U. Lindner, K.J. Fricke, J. Einasto, M. Einasto   +3 more
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Prospective evaluation of clinical voiding reeducation or voiding school for lower urinary tract conditions in children

, 2011
Purpose: We conducted a prospective controlled study evaluating the results of a clinical voiding reeducation program (voiding school) for treatment of lower urinary tract conditions in children compared to no treatment.
Van den Broeck, Christine, L. De Schrijver, A. Schoenaers, J. Vande Walle, Schoenaers, Alien, Deschepper, Ellen, C. Van den Broeck, Leenaerts, Ellen, De Schrijver, Lynn, Vande Walle, Johan, E. Deschepper, E. Leenaerts, P. Hoebeke, C. Renson, M. De Schryver, Renson, Catherine, Hoebeke, Piet, De Schryver, Mieke   +17 more
core   +1 more source

Voiding dynamics in women with urinary incontinence but without voiding symptoms

, 2020
Aims To describe the voiding pattern (VP) of women with urinary incontinence but without voiding symptoms and compare their clinical and urodynamic features between those voiding with and without a measurable detrusor contraction (DET-cont).
Naser Nassar, Michel, Valdevenito Sepúlveda, Juan, Alejandro Mercado‐Campero, Castro Caperan, Daniela, Marta Ledesma, Ledesma, Marta, Leandro Arribillaga, Juan P. Valdevenito, Michel Naser, Daniela Castro, Mercado Campero, Alejandro, Arribillaga, Leandro   +11 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Urethral multiplicity in boys: systematic review of case reports and case series from the last 15 years

Frontiers in Pediatrics
IntroductionUrethral multiplicity is a rare congenital anomaly characterized by the presence of two or more urethral channels. It is more common in males and can cause double urinary stream, incontinence, obstruction, and recurrent urinary infections ...
Horea Gozar, Horea Gozar, Zsolt Bara, Zsolt Bara, Evelyn Kovacs, Iulia Gozar, Zoltan Derzsi, Zoltan Derzsi   +7 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source