Results 101 to 110 of about 339,821 (318)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

On an Analytical Framework for Voids: Their abundances, density profiles and local mass functions

, 2006
We present a general analytical procedure for computing the number density of voids with radius above a given value within the context of gravitational formation of the large scale structure of the universe out of Gaussian initial conditions. To this end
Aikio, Appel, Bardeen, Benson, Betancort-Rijo, Betancort-Rijo, Betancort-Rijo, Betancort-Rijo, Bond, Colberg, Colless, Conroy, Croton, Davies, De Lapparent, Dey, Dressler, El-Ad, El-Ad, El-Ad, F. Prada, Friedmann, Gao, Geller, Gottlöber, Hoyle, Hoyle, Huchra, J. Betancort-Rijo, Jenkins, Kauffmann, Kauffmann, Kauffmann, Kirshner, Mathis, Mo, Müller, Müller, Otto, Patiri, Peebles, Peebles, Plionis, Politzer, Press, Rojas, S. G. Patiri, Sheth, Sheth, Sheth, Sommerville, Sommerville, Stoughton, Szomoru, Szomoru, Van De Weygaert, Vogeley, Vogeley, White   +58 more
core   +2 more sources

Impact of Land Use Changes on some Soil Micromorphological Features in Rakat Watershed, Eastern Khuzestan Province

علوم آب و خاک, 2020
The objective of this study was to investigate the impact of land use change (forest and rangelands to agriculture) on some micromorphological indices of soil quality in part of Rakat watershed, southwest of Iran.
P. Heidari, S. Hojati, N. Enayatzamir, A. Rayatpisheh   +3 more
doaj  

Geomechanical analysis of the impact of the new tunnels construction in the vicinity of existing underground subway structures on the state of the soil massif

Записки Горного института, 2023
The specificity of the behavior of the soil massif near the tunnel under construction in difficult mining conditions is considered. It was revealed through the joint interpretation of the results of geophysical measurements in the tunnel and computer ...
Vladimir V. Nabatov, Aleksandr S. Voznesenskii   +1 more
doaj  

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Grain boundary dynamics driven by magnetically induced circulation at the void interface of 2D colloidal crystals

, 2022
Dana M. Lobmeyer, Sibani Lisa Biswal
openalex   +1 more source

Prediction Model for Etiologic Differentiation of Isolated Vestibular Syndrome in Emergency Settings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to develop and validate a predictive model for differentiating central from peripheral etiologies in patients with isolated vestibular syndrome (VS). Methods In this multicenter retrospective cohort study, 506 patients with isolated VS from five hospitals were divided into derivation (n = 301) and validation (n = 205)
Guo Wenting, Du Liping, Yang Yi, Hu Jin, Ye Bijun, Wang Jianer, Liu Shuangsi, Guo Shunyuan, Cai Xiaofeng, Wang Huiyuan, Wu Bin, Yu Xiang, Shi Tianming   +12 more
wiley   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

A Simulation Study of FRP-PCM Reinforcement for Tunnel Linings with Void Defects

Applied Sciences
Voids behind tunnel linings can be formed either during or after the construction phase, occurring due to inadequate backfilling, substandard workmanship, water erosion, or gravitational forces.
Qiwei Lin, Yujing Jiang, Jing Wang, Satoshi Sugimoto   +3 more
doaj   +1 more source

Autosomal Recessive Spastic Ataxia of Charlevoix‐Saguenay in Two Half‐Siblings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Autosomal recessive spastic ataxia of Charlevoix‐Saguenay (ARSACS) is caused by biallelic pathogenic variants in the SACS gene. We report the clinical, radiologic and neurophysiologic features of a pair of half‐siblings who presented with progressive cerebellar ataxia, peripheral neuropathy and upper motor neuron signs.
Dennis Yeow, Matthew Katz, Jonathan Rodgers, Mark Davis, Thomas Robertson, R. J. McKinlay Gardner, Pamela A. McCombe   +6 more
wiley   +1 more source