Results 101 to 110 of about 94,980 (310)

Object grasping and manipulation in capuchin monkeys (genera Cebus and Sapajus) [PDF]

, 2018
The abilities to perform skilled hand movements and to manipulate objects dexterously are landmarks in the evolution of primates. The study of how primates use their hands to grasp and manipulate objects in accordance with their needs sheds light on how ...
Carducci, P., Sabbatini, G., Truppa, V.
core   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Difficulty in Fixation of the Volar Lunate Facet Fragment in Distal Radius Fracture

Case Reports in Orthopedics, 2017
Recent reports suggest the presence of a rare fracture type for which reduction and fixation cannot be achieved with volar locking plate (VLP). In particular, it is difficult to achieve reduction and fixation with volar lunate facet (VLF) fragments ...
Hiroyuki Obata, Tomonori Baba, Kentaro Futamura, Osamu Obayashi, Atsuhiko Mogami, Hideki Tsuji, Yoshiaki Kurata, Kazuo Kaneko   +7 more
doaj   +1 more source

Volar plate avulsion fracture alone or concomitant with collateral ligament rupture of the proximal interphalangeal joint: A comparison of surgical outcomes

Archives of Plastic Surgery, 2018
Background Volar plate avulsion fracture of the proximal interphalangeal (PIP) joint is one of the most common hand injuries. In this study, we divided patients into two groups: patients with pure volar plate avulsion fracture, and patients ...
Yong Woo Kim, Si Young Roh, Jin Soo Kim, Dong Chul Lee, Kyung Jin Lee   +4 more
doaj   +1 more source

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

Advanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du, Eun Seo Bae, Thinh T. M. Bui, Seok Beom Lee, Dahan Kim, Jin‐Gyeong Park, Yongjoo Park, Soo Yeon Park, Sangwook Kang, Beomsu Lee, Daniel Shin, Yun Pyo Kang, In‐Gyun Lee, Dae‐Duk Kim, Seokhee Kim, Suckchang Hong, Kyuho Moon, Sang Kook Lee, Dong‐Chan Oh   +18 more
wiley   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Acral (volar—subungual) melanoma

Journal of British Surgery, 1985
Abstract Acral melanoma occurs in the volar surface of the hands, feet, fingers, toes and subungual sites. Recently it has been recognized as a distinct entity with characteristic clinical and pathological features. Of our 340 patients with malignant melanoma, 24 (7 per cent) had acral melanoma.
M, Gutman, J M, Klausner, M, Inbar, Y, Skornick, M, Baratz, R R, Rozin   +5 more
openaire   +2 more sources

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

An investigation of ecological correlates with hand and foot morphology in callitrichid primates [PDF]

, 2013
Studies of primate taxonomy and phylogeny often depend on comparisons of limb dimensions, yet there is little information on how morphology correlates and contributes to foraging strategies and ecology.
Anapol, Anderson, Araújo, Ayres, Bicca-Marques, Bicca-Marques, Biegert, Bock, Burity, Burity, Cartmill, Cartmill, Cartmill, Chaves, Connour, Corrêa, Cortés-Ortiz, Crompton, Cunha, da Fonseca, da Silva, de Castro, Demes, Demes, Dietz, Digby, Dominy, Egler, Falsetti, Feduccia, Ferrari, Ferrari, Ferrari, Forsythe, Garber, Garber, Garber, Garber, Garber, Garber, Garber, Garber, Garber, Garber, Garber, Garber, Garber, Gebo, Haffner, Hamrick, Hamrick, Hanna, Henneberg, Heymann, Heymann, Hill, Hilário, Hoffman, Hunt, Jackson, Kirk, Krakauer, Lapenta, Lehman, Lemelin, Lemelin, Lemelin, Lemelin, Loesch, Lopes, Martin, Martins, Miranda, Munger, Nadjafzadeh, Napier, Nash, Natori, Norberg, Oliveira, Pastorini, Perelman, Peres, Peres, Peres, Peres, Pike, Porter, Porter, Porter, Porter, Porter, Porter, Poveda, Raboy, Raboy, Regan, Rehg, Ribas, Rosenberg, Rosenberger, Rylands, Rylands, Rylands, Rylands, Schmidt, Schmidt, Schmitt, Schmitt, Shoshani, Smith, Smith, Soligo, Soligo, Stephenson, Sussman, Thorndike, Tulli, van Roosmalen, van Valkenburgh, Veracini, Vinyard, Wright, Yoneda, Yoneda, Youlatos, Youlatos, Youlatos, Young, Yépez, Zani   +130 more
core   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source