Results 31 to 40 of about 38,057 (315)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Fractal Analysis of Volcanic Rock Image Based on Difference Box-Counting Dimension and Gray-Level Co-Occurrence Matrix: A Case Study in the Liaohe Basin, China

open access: yesFractal and Fractional
Volcanic rocks, as a widely distributed rock type on the earth, are mostly buried deep within basins, and their internal structures possess characteristics by irregularity and self-similarity.
Sijia Li, Zhuwen Wang, Dan Mou
doaj   +1 more source

Evaluation of volcanic gas reservoir in Yingcheng formation of Block Shengshen2-1 of Northern Part of Songliao Basin [PDF]

open access: yesE3S Web of Conferences, 2019
According to the thin sections of volcanic rocks, chemical composition analysis and log interpretation, and well data, it is determined that the volcanic rocks of Yingcheng Formation in Shengshen 2-1 block are mainly intermediate-acid volcanic lava and ...
Zhou Yue, Wu Haibo
doaj   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang   +17 more
wiley   +1 more source

Linking the Wrangellia flood basalts to the Galápagos hotspot

open access: yesScientific Reports, 2021
The Triassic volcanic rocks of Wrangellia erupted at an equatorial to tropical latitude that was within 3000 km of western North America. The mafic and ultramafic volcanic rocks are compositionally and isotopically similar to those of oceanic plateaux ...
J. Gregory Shellnutt   +2 more
doaj   +1 more source

Geochemistry of volcanic rocks from the Sunda Arc [PDF]

open access: yes, 2013
Geochemical analyses of igneous rocks can provide valuable information about processes, element fluxes, and rock lithologies not evident at the surface.
DEMPSEY, SCOTT,ROBERT
core  

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

open access: yesAdvanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia   +17 more
wiley   +1 more source

Seismic Stratigraphy and Geomorphology of Palaeocene Volcanic Rocks, Faroe-Shetland Basin [PDF]

open access: yes, 2013
2D and 3D seismic reflection data in the Faroe-Shetland Basin have been used to remotely study buried, large-scale Palaeocene volcanic structures emplaced during continental flood basalt volcanism in the Faroe-Shetland Basin.
WRIGHT, KIRSTIE,ANNE-MARIE
core  

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

open access: yesAdvanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su   +10 more
wiley   +1 more source

Distribution and gas-bearing properties of Permian igneous rocks in Sichuan Basin, SW China

open access: yesPetroleum Exploration and Development, 2019
Based on the analysis of outcrop, seismic, logging and drilling data, combined with exploration practice, the characteristics, distribution, reservoir performance and gas-bearing properties of Permian igneous rocks in Sichuan Basin are studied. The study
Xinhua MA   +7 more
doaj   +1 more source

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