Results 31 to 40 of about 10,789 (218)

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Distribution and gas-bearing properties of Permian igneous rocks in Sichuan Basin, SW China

Petroleum Exploration and Development, 2019
Based on the analysis of outcrop, seismic, logging and drilling data, combined with exploration practice, the characteristics, distribution, reservoir performance and gas-bearing properties of Permian igneous rocks in Sichuan Basin are studied. The study
Xinhua MA, Guohui LI, Danlin YING, Benjian ZHAGN, Ya LI, Xin DAI, Yi FAN, Yunxian ZENG   +7 more
doaj   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Exploration breakthrough and hydrocarbon accumulation conditions of Mesozoic volcanic rocks in Bodong Low Uplift, Bohai Bay Basin, China

Petroleum Exploration and Development
The Mesozoic volcanic rocks of the Bodong Low Uplift in the Bohai Bay Basin have been studied and explored for years. In 2024, the LK7-A well drilled in this region tested high-yield oil and gas flows from volcanic weathered crust.
Changgui XU, Haifeng YANG, Lei CHEN, Yanfei GAO, Shaofeng BU, Qi LI   +5 more
doaj   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Volcanic rocks in the 21st century: Multifaceted applications for sustainable development

Green Technologies and Sustainability
Volcanic rocks, with their diverse physicochemical properties, are pivotal in numerous scientific and industrial applications. This review comprehensively examines the multifaceted uses of volcanic rocks, focusing on their roles in sustainable ...
Hang Yang, Hongli Diao, Shibin Xia
doaj   +1 more source

The Archaean to Proterozoic igneous rocks of the Pilbara region, Western Australia –internationally significant geology of a globally unique potential geopark

International Journal of Geoheritage and Parks, 2019
The Pilbara region of Western Australia, covering some 500 km × 500 km, provides a diversity of Archaean to Proterozoic igneous rocks in a relatively compact area that records a younging southward crustal history of igneous activity, sedimentation, early
V. Semeniuk, M. Brocx
doaj   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

The Volcanic Rocks and Hydrocarbon Accumulation in the Offshore Indus Basin, Pakistan

Journal of Marine Science and Engineering
To analyze the impact of volcanic rocks in the Offshore Indus Basin on hydrocarbon reservoir formation, seismic data interpretation, seismic data inversion, and sea–land correlation analysis were carried out.
Jing Sun, Jie Liang, Jianming Gong, Jing Liao, Qingfang Zhao, Chen Zhao   +5 more
doaj   +1 more source