Results 81 to 90 of about 623,919 (404)

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Volcanic Evolution of the Southern Mountain Neogene Magmatic Belt in Baturagung Range Central Java, Indonesia

JGEET: Journal of Geoscience, Engineering, Environment and Technology
Various Neogene volcanic rocks associated with calcareous sediments compose the Southern Mountain located from Imogiri at Yogyakarta to Wonogiri at Central Java, Indonesia.
Sri Mulyaningsih, Rahel Putong, Anka Prima, Radhtya Adzan Hidayah, Desi Kiswiranti   +4 more
doaj   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Petrology and Geochemistry of Intrusive Rocks in the Tanjung Area, South Sulawesi, Indonesia: Implications for Magma Origin, Source Materials, and Geodynamic Setting

Iraqi Geological Journal
The origin of magma, source materials, and geodynamic setting of plutonic and volcanic rocks was elucidated by studying the characteristics of the rocks in the Tanjung area, South Sulawesi, Indonesia.
Hasbi Bakri, Imran Imran, Ulva Irvan, Adi Maulana   +3 more
doaj   +1 more source

Granitic rocks and metasediments in Archean crust, Rainy Lake area, Ontario: ND isotope evidence for mantle-like SM/ND sources [PDF]

Granitoids, felsic volcanic rocks and clastic metasediments are typical rocks in Archean granite-greenstone belts that could have formed from preexisting continentasl crust.
Hanson, G. N., Shirey, S. B.
core   +1 more source

Earth's rotation variability triggers explosive eruptions in subduction zones [PDF]

, 2015
The uneven Earth’s spinning has been reported to affect geological processes, i.e. tectonism, seismicity and volcanism, on a planetary scale. Here, we show that changes of the length of day (LOD) influence eruptive activity at subduction margins ...
CUFFARO, Marco, DOGLIONI, Carlo, PALLADINO, Danilo Mauro, SOTTILI, Gianluca   +3 more
core   +2 more sources

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Formation mechanisms and distribution of weathered volcanic reservoirs: A case study of the carboniferous volcanic rocks in Northwest Junggar Basin, China

Energy Science & Engineering, 2020
In view of the complex reservoir heterogeneities within weathered volcanic rocks, taking the Carboniferous volcanic weathered profile reservoir of the northwest Junggar Basin as an example, this study aims to characterize weathered volcanic rocks by the ...
Cunhui Fan, Hu Li, Qirong Qin, Ling Shang, Yunfeng Yuan, Zhi Li   +5 more
doaj   +1 more source

Geochemistry of volcanic rocks from the Wawa greenstone belt [PDF]

The Wawa greenstone belt is located in the District of Algoma and extends east-northeast from Lake Superior to the western part of the Sudbury District in Ontario, Canada.
Attoh, K., Schulz, K. J., Sylvester, P. J.   +2 more
core   +1 more source

Guide to the geology of Bradgate Park and Swithland Wood, Charnwood Forest [PDF]

, 2010
Charnwood Forest is one of the few parts of England where there are exposures of ‘basement’ rocks dating back to Precambrian time. Its locally rugged topography is caused by these highly resistant rocks protruding as craggy knolls through a surrounding ...
Carney, J.N.
core