Results 61 to 70 of about 424,073 (293)
Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, EarlyView.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
Petroleum Exploration and Development, 2013 To understand the planar and three-dimensional geometry of hydraulic fractures in volcanic rocks, a hydraulic fracturing simulation experiment was conducted using the large-scale triaxial hydraulic fracturing test system in laboratory.
Lichun JIA +7 more
doaj +1 more source
Jurassic–Paleogene intraoceanic magmatic evolution of the Ankara Mélange, north-central Anatolia, Turkey [PDF]
Solid Earth, 2014 Oceanic rocks in the Ankara Mélange along the Izmir–Ankara–Erzincan suture zone (IAESZ) in north-central Anatolia include locally coherent ophiolite complexes (~ 179 Ma and ~ 80 Ma), seamount or oceanic plateau volcanic units with pelagic and reefal ...
E. Sarifakioglu, Y. Dilek, M. Sevin
doaj +1 more source
Rudarsko-geološko-naftni Zbornik, 2021 Junggar Basin is one of the largest sedimentary basins in Northwest China. Carboniferous oil and gas fields have been found in different areas in the eastern part of the Junggar Basin on a large scale, indicating that the Carboniferous rocks of the ...
Masab Ali +3 more
doaj +1 more source
Advanced Science, EarlyView.We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen +5 more
wiley +1 more source
CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer
Advanced Science, EarlyView.Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano +10 more
wiley +1 more source
The origin of Proterozoic massif-type anorthosites: Evidence from interactions between crustal xenoliths and basaltic magma [PDF]
, 1999 Plagioclase-rich reaction zones occur around numerous aluminous crustal xenoliths within a suite of Palaeogene sub-volcanic basic sheets on the Isle of Mull, NW Scotland.
Preston, R.J. +2 more
core +5 more sources
Advanced Science, EarlyView.Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong +10 more
wiley +1 more source
Contorted stratification with clay lobes in volcanic ash beds, Raglan-Hamilton region, New Zealand [PDF]
, 1970 Contorted stratification in basal volcanic ash beds of the Pleistocene Hamilton Ash Formation incorporates halloysitic clay lobes which project upward into a bed of predominantly allophanic material.
Tonkin, Philip J.
core
Advanced Science, EarlyView.Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang +12 more
wiley +1 more source