Results 91 to 100 of about 173,383 (330)
Deep drilling into a Hawaiian volcano [PDF]
, 2001 Hawaiian volcanoes are the most comprehensively studied on Earth. Nevertheless, most of the eruptive history of each one is inaccessible because it is buried by younger lava flows or is exposed only below sea level.
DePaolo, Donald J. +2 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Tectonic setting of Martian volcanoes and deep-seated intrusives [PDF]
More than 50 volcanoes have been mapped on Mars, and recent geologic studies indicate structural evidence of deep seated intrusive bodies. Most volcanoes in the Tharsis region are volcanotectonic features; they have been associated with large scale ...
Dohm, James M., Scott, David H.
core +1 more source
Sea-floor tectonics and submarine hydrothermal systems [PDF]
, 2005 The discovery of metal-depositing hot springs on the sea floor, and especially their link to chemosynthetic life, was among the most compelling and significant scientific advances of the twentieth century. More than 300 sites of hydrothermal activity and
de Ronde, Cornell D. J. +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Remote SensingThe Flexible Combined Imager (FCI) instrument aboard the Meteosat Third Generation (MTG-I) geostationary satellite, launched in December 2022 and operational since September 2024, by providing shortwave infrared (SWIR), medium infrared (MIR) and thermal ...
Carolina Filizzola +4 more
doaj +1 more source
, 2019 Arabia Terra is a region of Mars where signs of past-water occurrence are recorded in several landforms. Broad and local scale geomorphological, compositional and hydrological analyses point towards pervasive fluid circulation through time.
Cremonese, Gabriele +6 more
core +1 more source
Ages of the Pliocene-Pleistocene Alexandra and Ngatutura Volcanics, western North Island, New Zealand, and some geological implications [PDF]
, 1989 The Alexandra and Ngatutura Volcanics are the two southernmost of the Pliocene-Quaternary volcanic fields of western and northern North Island, New Zealand, northwest of Taupo Volcanic Zone TVZ.
Briggs, Roger M. +3 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A clustering-based repeating earthquakes identification method and its application
地球与行星物理论评Events with highly similar waveforms and rupturing of the same fault patch are interpreted as repeating earthquakes, which can be applied in detecting deep fault deformation, characterizing fault behavior, and assess seismic hazards.
Yafen Huang +4 more
doaj +1 more source