Results 121 to 130 of about 181,923 (329)

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

open access: yesAdvanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu   +10 more
wiley   +1 more source

A deformation-driven earthquake interaction model for seismicity at Campi Flegrei

open access: yesCommunications Earth & Environment
Since 2005, the Campi Flegrei nested caldera volcano, located about 10 km west of Naples, Italy, has experienced accelerating uplift accompanied by increased seismicity, raising concerns in this densely populated area.
Sebastian Hainzl   +2 more
doaj   +1 more source

Engineering Extracellular Vesicle Production Through Magnetic Ion Channel Activation for Bone Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan   +9 more
wiley   +1 more source

Eldgjá and Laki: Two large Icelandic fissure eruptions and a historical-critical approach for interdisciplinary researchers working on past nature-induced disasters

open access: yesVolcanica
The integration of archives of societies with archives of nature has led to collaborations between the natural sciences and the humanities. Not all those involved consider these archives equal, which led to some studies featuring explanations promoting ...
Stephan F. Ebert, Katrin Kleemann
doaj   +1 more source

Multiverse Predictions for Habitability: Fraction of Life that Develops Intelligence

open access: yes, 2019
Do mass extinctions affect the development of intelligence? If so, we may expect to be in a universe that is exceptionally placid. We consider the effects of impacts, supervolcanoes, global glaciations, and nearby gamma ray bursts, and how their rates ...
Sandora, McCullen
core   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

open access: yesAdvanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum   +5 more
wiley   +1 more source

Volcanoes and global catastrophes [PDF]

open access: yes
The search for a single explanation for global mass extinctions has let to polarization and the controversies that are often fueled by widespread media attention.
Simkin, Tom
core   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

open access: yesAdvanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li   +9 more
wiley   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

open access: yesAdvanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens   +3 more
wiley   +1 more source

Volcanoes [PDF]

open access: yesAmerican Journal of Kidney Diseases, 2018
openaire   +2 more sources

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