Results 41 to 50 of about 371 (218)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Capacitor voltage balancing control with reducing the average switching frequency in MMC

open access: yesThe Journal of Engineering, 2019
Modular multilevel converter (MMC) has a very good application prospect in the flexible high-voltage direct current (HVDC) transmission, but higher self-loss will affect the efficiency and restrict the development.
Shunliang Wang   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Transient stability analysis of virtual synchronous generator with current saturation by multiple Lyapunov functions method

open access: yesIET Generation, Transmission & Distribution
This paper demonstrates that the switching of one grid‐connected virtual synchronous generator (VSG) between two control modes, namely constant voltage control (CVC) and current limiting control (CLC) happens at the derived two switching lines.
Yujun Li   +4 more
doaj   +1 more source

Control of a synchronverter-based soft open point in a distribution network

open access: yesThe Journal of Engineering, 2019
The presence of distributed generation (DG) in a power distribution network can cause difficulties in managing the voltage, power flow and fault level as the network was designed for supplying passive loads. This study focuses on the control of a back-to-
Ruizhu Wu   +3 more
doaj   +1 more source

Availability assessment of voltage source converter HVDC grids using optimal power flow-based remedial actions

open access: yesHigh Voltage, 2020
This study proposes a methodology for assessing the availability of voltage source converter high-voltage direct current (HVDC) grids based on the enumeration methodology of contingency analysis with N − 2 criteria and makes contributions in the ...
Mario A. Rios   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evaluation of DC-link voltage ripple in five-phase PWM voltage source inverters

open access: yesThe Journal of Engineering, 2019
This paper presents the analysis of the DC-link voltage switching ripple in five-phase PWM voltage source inverters with balanced load. The analysis is particularly important for the design and selection of a DC-link capacitor making it possible to meet ...
M. Vujacic   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy