Results 61 to 70 of about 371 (218)

Analysis of DC voltage oscillation mechanism in AC/DC hybrid distribution system

open access: yesThe Journal of Engineering, 2019
DC voltage oscillation occurs more and more frequently in voltage source converter (VSC)-based AC/DC hybrid distribution system (AC/DC HDS). However, currently, the explanation of the oscillation mechanism is not clear enough.
Luyang Li   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Parallel current-controlled synchronverters for voltage and frequency regulation in weak grids

open access: yesThe Journal of Engineering, 2019
The emulation of synchronous machines is becoming an attractive solution to provide virtual inertia and voltage support to weak grids and microgrids, representing an alternative to conventional current-injection control strategies.
Javier Roldán-Pérez   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

High-voltage switch-mode assisted linear amplifier based voltage source for dielectric low frequency-domain spectroscopy measurements

open access: yesThe Journal of Engineering, 2019
This study presents a switch-mode assisted linear amplifier (SMALA) designed for use as a frequency-domain spectroscopy (FDS) excitation voltage source for the diagnostic testing of oil/paper insulation systems in large power transformers.
Shawn D. Nielsen   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Corrected complex torque coefficient method for synchronization stability analysis of grid‐connected VSC

open access: yesIET Renewable Power Generation
Sub‐synchronous oscillation of grid‐connected voltage source converter (VSC) dominated by phase locked loop (PLL) is an important stability issue in nowadays power systems.
Boyuan Zhao   +4 more
doaj   +1 more source

Review of low voltage ride-through technology of doubly-fed induction generator

open access: yesThe Journal of Engineering, 2019
In recent years, with the increasing of wind power development, the demand for low voltage ride-through (LVRT) technology was proposed to ensure the safe and reliable operation of the power system.
Lele Niu   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Loss reduction analysis and control of AC-voltage-boosted FBSM MMC by injecting second harmonic circulating current

open access: yesThe Journal of Engineering, 2019
Reducing the power loss and handling short-circuit faults in HVDC systems are crucial for economical and reliable operation of modular multilevel converters (MMC). This paper proposes a loss reduction method for AC voltage-boosted FBSM-MMC by controlling
Muchao Xiang, Jiabing Hu, Zhiyuan He
doaj   +1 more source

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