Results 71 to 80 of about 371 (218)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Improved Step‐Up Z‐Source Inverter Based on Symmetric Switched Capacitor and Inductor

IET Power Electronics
This paper introduces a new switched‑inductor Z‑source inverter topology that employs a capacitor‑assisted inductor network, achieving a significantly higher voltage‑gain factor while simultaneously reducing capacitor voltage stress over an extended duty‑
Masoumeh Gholami, Reza Noroozian, Mehran Moslehi Bajestan   +2 more
doaj   +1 more source

The overhead transmission line protection scheme for the voltage-source converter-based HVDC grids

The Journal of Engineering, 2019
The fast DC line protection technology is one of the main challenges to high-voltage direct current (HVDC) grids. Based on the Zhangbei HVDC grid project, this paper proposes a non-unit overhead transmission line protection scheme for bipolar voltage ...
Yanting Wang, Baohui Zhang, Baohui Zhang, Xinkai Fan   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Research on coordinated reactive power control strategy of hybrid-HVDC

The Journal of Engineering, 2019
Based on the hybrid HVDC transmission system, which is composed by line-commutated converter (LCC) in parallel with voltage source converter (VSC), a coordinated reactive power control strategy of hybrid-HVDC in both steady and transient states is ...
Ying Huang, Chunhua Li, Tao Liu
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Hybrid ultra-HVDC system with LCC and cascaded hybrid MMC

The Journal of Engineering, 2019
Nowadays, the hybrid high-voltage direct current (HVDC) system consisting of line commutated converter (LCC) and modular multilevel converter (MMC) has become the most competitive candidate in multi-infeed power systems.
Ruizhang Yang, Wang Xiang, Weixing Lin, Jinyu Wen   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source