Results 71 to 80 of about 248,505 (393)

Unraveled roles of Cav1.2 in proliferation and stemness of ameloblastoma

Cell & Bioscience, 2022
Background Transcriptome analysis has been known as a functional tool for cancer research recently. Mounting evidence indicated that calcium signaling plays several key roles in cancer progression.
Shujin Li, Dong-Joon Lee, Hyun-Yi Kim, Jun-Young Kim, Young-Soo Jung, Han-Sung Jung   +5 more
doaj   +1 more source

Glutamate 73 Promotes Anti-arrhythmic Effects of Voltage-Dependent Anion Channel Through Regulation of Mitochondrial Ca2+ Uptake

Frontiers in Physiology, 2021
Mitochondria critically regulate a range of cellular processes including bioenergetics, cellular metabolism, apoptosis, and cellular Ca2+ signaling. The voltage-dependent anion channel (VDAC) functions as a passageway for the exchange of ions, including ...
Hirohito Shimizu, Simon Huber, Adam D. Langenbacher, Lauren Crisman, Jie Huang, Kevin Wang, Fabiola Wilting, Thomas Gudermann, Thomas Gudermann, Johann Schredelseker, Johann Schredelseker, Jau-Nian Chen   +11 more
doaj   +1 more source

Voltage‐dependent inactivation in a cardiac‐skeletal chimeric calcium channel [PDF]

FEBS Letters, 1995
The loci for inactivation in calcium channel proteins are unknown. Mechanisms for inactivation may be distributed across Ca2+ channel subunits and appear to be complex, multiple and interacting. We took advantage of the properties of chimeras, constructed between cardiac (H4) and skeletal muscle (Sk4) calcium channel α 1 subunits to study the molecular
M Gopalakrishnan, Edward Perez-Reyes, Antonio E. Lacerda, Xiangyang Wei, L Parent   +4 more
openaire   +3 more sources

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

New Insights in CaVβ Subunits: Role in the Regulation of Gene Expression and Cellular Homeostasis

Frontiers in Cell and Developmental Biology, 2022
The voltage-gated calcium channels (CaVs or VGCCs) are fundamental regulators of intracellular calcium homeostasis. When electrical activity induces their activation, the influx of calcium that they mediate or their interaction with intracellular players
Amélie Vergnol, Massiré Traoré, France Pietri-Rouxel, Sestina Falcone   +3 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel [PDF]

, 2001
Hair cells in mouse cochlear cultures are selectively labeled by brief exposure to FM1-43, a styryl dye used to study endocytosis and exocytosis. Real-time confocal microscopy indicates that dye entry is rapid and via the apical surface.
Gale, J.E., Kennedy, H.J., Kros, C.J., Marcotti, W., Richardson, G.P.   +4 more
core   +1 more source

Rocker Is a New Variant of the Voltage-Dependent Calcium Channel Gene Cacna1a

Journal of Neuroscience, 2001
Rocker (gene symbol rkr), a new neurological mutant phenotype, was found in descendents of a chemically mutagenized male mouse. Mutant mice display an ataxic, unstable gait accompanied by an intention tremor, typical of cerebellar dysfunction. These mice
T. Zwingman, P. Neumann, J. Noebels, K. Herrup   +3 more
semanticscholar   +1 more source

G protein-induced trafficking of voltage-dependent calcium channels. [PDF]

Journal of Biological Chemistry, 2006
Calcium channels are well known targets for inhibition by G protein-coupled receptors, and multiple forms of inhibition have been described. Here we report a novel mechanism for G protein-mediated modulation of neuronal voltage-dependent calcium channels that involves the destabilization and subsequent removal of calcium channels from the plasma ...
Ryan W. Richman, Natasha Permaul, Jennifer Rodriguez, Nory Jun Cabanilla, Paul Carman, María A. Diversé-Pierluissi, Robert F. Hennigan, Dan P. Felsenfeld, Eugene Tombler, Jessica Lee, John J. Hall   +10 more
openaire   +4 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source