Results 111 to 120 of about 120,489 (308)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Non‐Uniform Voltage Balancing Methods for Series‐Connected SiC MOSFETs in High‐Frequency Fast Switching

IET Power Electronics
A half‐bridge circuit formed by series‐connected silicon carbide metal‐oxide‐semiconductor field‐effect transistors (SiC MOSFETs) generates high‐frequency, high‐voltage pulses with a fast rising time, widely used in electro‐optical modulators ...
Yixin Shi, Dingmeng Guo, Xiaoning Zhang, Yaogong Wang, Xiaoqin Ma, Rui Fan   +5 more
doaj   +1 more source

Smart grids for rural conditions and e-mobility - Applying power routers, batteries and virtual power plants [PDF]

, 2016
Significant reductions of greenhouse gas emission by use of renewable energy sources belong to the common targets of the European Union. Smart grids address intelligent use and integration of conventional and renewable generation in combination with ...
Boehner, Volker, Franz, P., Gallart, R, Girbau Llistuella, Francesc, Hanson, J., Martínez, S., Sumper, Andreas   +6 more
core  

Voltage Balance Monitoring Based on Voltage’s Instantaneous Space Phasor Geometrical Loci

RE&PQJ
The paper introduces a new approach for voltage balance monitoring based on the computer-aided assessment of the network Instantaneous Voltage’s Space Phasor (IVSP). Between the voltage unbalances severities and the IVSP modulus ripples or the IVSP angular speed ripples are identified the appropriate correspondences which are used for voltage unbalance
null A. Crăciunescu, null G. Ciumbulea, null C. Necula Dumitrică, null M. Predescu   +3 more
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Modular multilevel converter based LCL DC/DC converter for high power DC transmission grids [PDF]

, 2015
This paper presents a modular multilevel converter (MMC) based DC/DC converter with LCL inner circuit for HVDC transmission and DC grids. Three main design challenges are addressed.
Aboushady, Ahmed, Ahmed, Khaled, Jovcic, Dragan   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A Method of Balancing Control for Capacitor Voltage of Modular Multilevel Converter

Kongzhi Yu Xinxi Jishu, 2012
This paper introduces the operation principle of modular multilevel converter and balancing control method of capacitor voltage. Considering the condition under external disturbance which may lead to outputting unbalanced voltage and waveform distortion ...
LI Yunfeng, SONG Pinggang, WANG Chu
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source