Results 31 to 40 of about 28,439 (245)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Performance Comparison of LCC and VSC HVDC Systems in Minimizing Long-Term Voltage Collapse
IEEE AccessHigh-voltage direct current (HVDC) transmission helps transmit large energy blocks over long distances. Line-Commutated Converters (LCC) and Voltage Source Converters (VSC) can be used for this purpose.
Renan Pinto Fernandes +3 more
doaj +1 more source
effects of facts devices voltage stability
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2013 In this study, the effect of STATCOM and SVC controllers are examined against the power system voltage collapse. Investigations were made IEEE 5 bus system. The computer simulation program was used for the PSAT.
Enes Talha Gümüş
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Ain Shams Engineering JournalVoltage stability ensures reliable and efficient power transmission to end-users, making it essential for power system efficiency. Dynamic load changes and rising power requirements might cause voltage instability and strain performance.
Hasan Saeed Qazi +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Studi Efektifitas Indikator Kestabilan Tegangan Pada Model Dinamis Sistem Tenaga Listrik
Semesta Teknika, 2016 The paper presents the effectiveness of voltage stability indices for dynamic power system modelling study in providing information about the proximity of voltage collapse in power system.
Muhammad Nizam
doaj
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source