Results 51 to 60 of about 120,545 (279)

An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels [PDF]

, 2009
Slow inactivation of Kv1 channels involves conformational changes near the selectivity filter. We examine such changes in Shaker channels lacking fast inactivation by considering the consequences of mutating two residues, T449 just external to the ...
Ader, Ahern, Amy L. Eastwood, Baukrowitz, Bernèche, Chakrapani, Chakrapani, Choi, Christopher A. Ahern, Cordero-Morales, Cordero-Morales, Cordero-Morales, Dennis A. Dougherty, Doyle, Foster, Goldstein, Grissmer, Heginbotham, Hoshi, Kavanaugh, Kiss, Klemic, Lenaeus, Liu, López-Barneo, Ma, MacKinnon, Molina, Murphy, Nowak, Nowak, Richard Horn, Saebo, Santarelli, Stansfeld, Starkus, Yeh, Yellen, Yellen, Yellen   +39 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Stability analysis and voltage improvement in DG-integrated distribution networks using VCPI-based critical buses and lines detection considering uncertain power factor

Ain Shams Engineering Journal
Voltage stability ensures reliable and efficient power transmission to end-users, making it essential for power system efficiency. Dynamic load changes and rising power requirements might cause voltage instability and strain performance.
Hasan Saeed Qazi, Zia Ullah, Ahmad Alferidi, Mohammed Alsolami, Badr Lami, Syed Muhammad Abrar Akber   +5 more
doaj   +1 more source

Determination of static voltage stability-margin of the power system prior to voltage collapse. [PDF]

, 2011
yesVoltage instability problems in power system are an important issue that should be taken into consideration during the planning and operation stages of modern power system networks.
Jalboub, Mohamed K., Ihbal, Abdel-Baset M.I., Rajamani, Haile S., Abd-Alhameed, Raed A.   +3 more
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Studi Efektifitas Indikator Kestabilan Tegangan Pada Model Dinamis Sistem Tenaga Listrik

Semesta Teknika, 2016
The paper presents the effectiveness of voltage stability indices for dynamic power system modelling study in providing information about the proximity of voltage collapse in power system.
Muhammad Nizam
doaj  

BESS based voltage stability improvement enhancing the optimal control of real and reactive power compensation

AIMS Energy, 2022
With the increase in the integration of renewable energy resources in the grid and ongoing growth in load demand worldwide, existing transmission lines are operating near their loading limits which may experience voltage collapse in a small disturbance ...
Habibullah Fedayi , Mikaeel Ahmadi , Abdul Basir Faiq , Naomitsu Urasaki, Tomonobu Senjyu   +4 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

New Performance Indices for Voltage Stability Analysis in a Power System

Energies, 2017
The frequent occurrence of voltage instability in a modern power system is alarming and thus, has been of great concern to power system utilities. In this paper, a new performance index based on the power flow solutions for voltage stability assessment ...
Isaiah Adebayo, Yanxia Sun
doaj   +1 more source