Results 51 to 60 of about 28,176 (317)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Inhomogeneity and transverse voltage in superconductors

open access: yes, 2011
Voltages parallel and transverse to electric current in slightly inhomogeneous superconductors can contain components proportional to the field and temperature derivatives of the longitudinal and Hall resistivities.
A. Gerber   +3 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Study of Grain Boundary Characters under Intergranular Corrosion in Copper Conductor and Its Relationship with Paper Oil Insulation in Transformer

open access: yesInternational Journal of Electrochemical Science, 2015
The properties of materials such as corrosion, creep resistance, and weld ability are relevant to special and random grain boundaries which belongs to the category of Grain Boundary Engineering (GBE).
Yuan Yuan   +4 more
doaj   +1 more source

Ultrastable low-noise current amplifier

open access: yes, 2014
An ultrastable low-noise current amplifier (ULCA) is presented. The ULCA is a non-cryogenic instrument based on specially designed operational amplifiers and resistor networks.
Ahlers, Franz Josef   +4 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

"Mirror Image" space charge distribution in XLPE power cable under opposite stressing voltage polarity [PDF]

open access: yes, 2005
The paper presents the research on space charge distribution under different polarities in full size cross-linked polyethylene power cables using the pulsed electro-acoustic technique.
Chen, G., Fothergill, J., Fu, M.
core  

New Experimental Limit on the Electric Dipole Moment of the Electron in a Paramagnetic Insulator

open access: yes, 2015
We report results of an experimental search for the intrinsic Electric Dipole Moment (EDM) of the electron using a solid-state technique. The experiment employs a paramagnetic, insulating gadolinium gallium garnet (GGG) that has a large magnetic response
Kim, Y. J.   +7 more
core   +1 more source

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