Results 61 to 70 of about 28,176 (317)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Effect of the Axial Heat Transfer on Space Charge Accumulation Phenomena in HVDC Cables

Energies, 2020
To date, it has been widespread accepted that the presence of space charge within the dielectric of high voltage direct current (HVDC) cables is one of the most relevant issues that limits the growing diffusion of this technology and its use at higher ...
Giuseppe Rizzo, Pietro Romano, Antonino Imburgia, Fabio Viola, Guido Ala   +4 more
doaj   +1 more source

Fully reversible magnetoelectric voltage controlled THz polarization rotation in magnetostrictive spintronic emitters on PMN-PT

Applied Physics Letters, 2022
THz polarization control upon generation is a crucially missing functionality. THz spintronic emitters based on the inverse spin Hall effect (ISHE) allow for this by the strict implicit orthogonality between their magnetization state and the emitted polarization.
G. Lezier, P. Koleják, J.-F. Lampin, K. Postava, M. Vanwolleghem, N. Tiercelin   +5 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Negative electrode catalyst for the iron chromium redox energy storage system [PDF]

, 1985
A redox cell which operates at elevated temperatures and which utilizes the same two metal couples in each of the two reactant fluids is disclosed. Each fluid includes a bismuth salt and may also include a lead salt.
Gahn, R. F., Hagedorn, N. H.
core   +1 more source

Valley filter and valley valve in graphene

, 2006
It is known that the lowest propagating mode in a narrow ballistic ribbon of graphene may lack the twofold valley degeneracy of higher modes. Depending on the crystallographic orientation of the ribbon axis, the lowest mode mixes both valleys or lies ...
A. Rycerz, AF Morpurgo, C Berger, C. W. J. Beenakker, E McCann, H van Houten, J Tworzydło, J. Tworzydło, K Nakada, K Wakabayashi, K Wakabayashi, KS Novoselov, L Brey, M Fujita, MI Katsnelson, NMR Peres, O Gunawan, PG Silvestrov, SA Wolf, SV Morozov, T Ando, V Cerletti, VV Cheianov   +22 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Surface Charge and Electric Field Distribution of Direct-Current Gas-Insulated Transmission Lines’ Basin-Type Insulators Under Multi-Field Coupling

Applied Sciences
In direct-current gas-insulated transmission lines (DC GIL), complex heat transfer processes accelerate surface charge accumulation on insulators, causing local electric field distortion and elevating the risk of surface flashover.
Junran Jia, Xin Lin, Zhenxin Geng, Jianyuan Xu   +3 more
doaj   +1 more source

Reverse voltage generating circuit for rapid commutation of output current polarity in variable polarity arc welding power supply

IET Power Electronics, 2017
The topology of variable polarity (VP) arc welding power supply is composed of a first inverting stage responsible for the adjustment of output current amplitude and a second inverting stage used for the commutation of output current polarity. A reverse voltage generating (RVG) circuit is proposed, which could be applied in the second inverting stage ...
Yang Zhong‐Yu, Zhu Zhi‐Ming, Liu Bo
openaire   +1 more source

Measurement of the Permanent Electric Dipole Moment of the $^{129}$Xe Atom

, 2019
We report on a new measurement of the CP-violating permanent Electric Dipole Moment (EDM) of the neutral $^{129}$Xe atom. Our experimental approach is based on the detection of the free precession of co-located nuclear spin-polarized $^3$He and $^{129 ...
Allmendinger, F., Engin, I., Heil, W., Karpuk, S., Krause, H. -J., Niederländer, B., Offenhäusser, A., Repetto, M., Schmidt, U., Zimmer, S.   +9 more
core   +1 more source