Results 81 to 90 of about 204,898 (264)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Optimal design and analysis of a grid‐connected hybrid renewable energy system using HOMER Pro: A case study of Tumbatu Island, Zanzibar

Energy Science & Engineering
This study addresses the pressing issue of quality electricity access in remote regions, with a specific focus on Tumbatu Island in Tanzania. Most studies on quality improvement concentrate on low‐voltage distribution lines and leave high‐voltage (HV ...
Thani R. Said, Baraka Kichonge, Thomas Kivevele   +2 more
doaj   +1 more source

Monotonicity Criterion-Based Power Quality Improvement in Distributed Energy Systems with Solar PV Integration [PDF]

Journal of Renewable Energy and Environment
This study investigates power quality improvement in a distributed energy system with a solar PV system, based on the monotonicity criterion. The research considered a range of IEEE bus systems—namely, the IEEE 14-bus, IEEE 33-bus, IEEE 57-bus, and IEEE ...
Phani Kumar Chittala, Elanchezhian E.B, Pragaspathy Subramani, Subramanian S   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

An Improved Genetic Algorithm for Optimal Stationary Energy Storage System Locating and Sizing

Energies, 2014
The application of a stationary ultra-capacitor energy storage system (ESS) in urban rail transit allows for the recuperation of vehicle braking energy for increasing energy savings as well as for a better vehicle voltage profile.
Bin Wang, Zhongping Yang, Fei Lin, Wei Zhao   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Capacitance-voltage Profiling Techniques for Characterization of Semiconductor Materials and Devices [PDF]

SSRN Electronic Journal, 2019
A new capacitance-voltage profiling technique of semiconductor junctions is proposed for characterisation of semiconductor materials and devices. The measurement technique is simple, non-destructive and it has a greater accuracy compared with the classical C-V method of J. Hilibrand and R. D. Gold, developed in 1960.
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source