Results 101 to 110 of about 565,077 (289)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

An Enhanced Modular Multilevel Converter With Flexible Interruption Capability of DC-Side Fault

IEEE Access, 2019
The modular multilevel converter (MMC) has a promising prospect in high voltage direct current (HVDC) transmission, while the application of MMC is limited by lacking of dc fault interruption capability.
Jun Mei, Pengfei Zhu, Lingxiao Yan, Guangyao Fan, Rui Ge, Bingbing Wang   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Wide Range Voltage Scaling Converter With Extended Duty and Low Voltage Stress for a DC Microgrid Applications

IEEE Open Journal of Industry Applications
DC–DC converters hold immense importance due to their diverse applications, making it critical to design them in accordance with the demanding operational requirements.
Md Samiullah, Mohammed Al-Hitmi, Ali T. Al Awami, Shirazul Islam, Atif Iqbal   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A Si-FET-Based High Switching Frequency Three-Level LLC Resonant Converter

Energies, 2019
This paper highlights the proposed silicon field-effect transistor (Si-FET)-based high switching frequency three-level (TL) LLC resonant converter. It provides a detailed operational analysis of the converter; the multilevel (ML) organization of cells ...
Jung-Woo Yang, Sang-Kyoo Han
doaj   +1 more source

Pathway to the PiezoElectronic Transduction Logic Device

, 2015
The information age challenges computer technology to process an exponentially increasing computational load on a limited energy budget - a requirement that demands an exponential reduction in energy per operation.
Armstrong, C., Bryce, B. A., Copel, M., Elmegreen, B. G., Gordon, M. S., Haensch, W., Hung, L. -W., Keech, R., Kuroda, M. A., Liu, X. -H., Martyna, G. J, Miyazoe, H., Newns, D. M., Reuter, K. B., Rossnagel, S. M., Schrott, A. G., Shaw, T. M., Shett, S., Solomon, P. M., Theis, T. N., Trolier-McKinstry, S.   +20 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Performance Investigation of Three-Phase Three-Switch Direct PWM AC/AC Voltage Converters

IEEE Access, 2019
Reducing the number of active switches is substantial for obtaining a simple, reliable, high-efficiency, and cost-effective AC/AC voltage converter. In this paper, two topologies of three-phase direct PWM AC/AC voltage converter are proposed.
Said A. Deraz, Haitham Z. Azazi, Mohamed S. Zaky, Mohamed K. Metwaly, Mohammed E. Dessouki   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source