Results 131 to 140 of about 13,354,243 (294)

Comparison of two close-packing methods for vertex placement in lattice radiotherapy (LRT). [PDF]

J Appl Clin Med Phys
Song Y, Ma P, Dai J.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A Dual-parameter 3D Assessment of Alveolar Cleft Bone Grafts: Integrating Bone Density and Modified Volumetry. [PDF]

Plast Reconstr Surg Glob Open
Deng M, Wei S, Wang Y.
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Sex Differences in Prescribing Patterns of Anticholinergics and β3-Adrenoceptor Agonists for Overactive Bladder: A Nationwide Study in Japan, FY2017-FY2024. [PDF]

Low Urin Tract Symptoms
Koike T, Kawahara T, Hashizume A, Yamazaki M, Takamoto D, Ito H, Takeshima T, Uemura H, Makiyama K, Teranishi JI.   +9 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Semina: Ci. Agrárias, Londrina, v. 23, n.2, jul./dez. 2002

Semina: Ciências Agrárias, 2009
Semina volume 23 n2
doaj   +1 more source

Post-embolization dynamic changes in Obsidio Conformable Embolic: volume and radiodensity analysis. [PDF]

CVIR Endovasc
Harraka M, Amin R, Pourmorteza A, Cohen EI, Afsari B, Sabri SS, Banovac F, Bomberger H, Jones J, Habibollahi P, Nezami N.   +10 more
europepmc   +1 more source

Dynamic Relations between Trading Volume Volatility and Liquidity: Evidence from “Oil Price Concept” Stocks

, 2016
[[abstract]]本文以2005年1月至2015年6月台灣證券交易所上市公司中的「油價概念股」為樣本，檢驗成交量、價格波動性與流動性的動態關係。我們利用聯立方程式去建構成交量、價格波動性與流動性的長期關係；以衝擊反應分析和預測誤差變異數分解二種方法分析成交量、價格波動性與流動性的短期相互影響關係。研究結果顯示，成交量、價格波動性與流動性存在長期關係，其中，成交量與價格波動性成正向關係，成交量與流動性成正向關係，價格波動性與流動性成負向關係。不同於長期關係，在短期裡，成交量對於流動性具有負向影響 ...
王盈仁, Wang, Ying-Jen
core  

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source