Results 141 to 150 of about 13,354,243 (294)

Progressive Hippocampal Volume Reduction Beyond Normal Aging in Temporal Lobe Epilepsy: A Longitudinal MRI Study. [PDF]

Epilepsia Open
Sone D, Shigemoto Y, Kagaya R, Kimura Y, Matsuda H, Sato N.   +5 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The Role of Measurement in Identifying High-Intensity Secure Message Senders Among Older Adults: Observational Study. [PDF]

J Med Internet Res
Wec A, Seale Reiff J, Gleason KT, Fabius CD, McGready J, Wolff JL.   +5 more
europepmc   +1 more source

Testing Alternative Theories of the Property Price-Trading Volume Correlation [PDF]

This article examines the correlation between the real housing price and trading volume. Contrary to the predictions of standard rational expectation models, a robust positive correlation between the two variables is identified.
Garion C. K. Lau, Youngman C. F. Leong, Charles K. Y. Leung   +2 more
core  

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Randomized, Controlled, Crossover Trial Comparing Immediate Effects of Components of Complex Decongestive Therapy in Lower-limb Lymphedema Patients. [PDF]

Prog Rehabil Med
Oka A, Tsuji T, Abe K, Nakamura T, Kawakami M, Muraoka K, Hohri H, Sano Y, Shoji J, Kamisako M, Liu M.   +10 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Temporal Change: Evaluation of Brain Atrophy in Patients with Radiologically Isolated Syndrome Using volBrain. [PDF]

Medicina (Kaunas)
Akkoç F, Alagöz AN, Bünül SD, Alparslan B, Efendi H.   +4 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Amygdala volume and psychiatric burden in focal epilepsy: PET evidence for a glial substrate. [PDF]

Brain Commun
Imhoff-Smith TP, McMillan A, Hurley SA, Kalkach Aparicio M, Nair V, Philibert-Rosas S, Binder JR, Meyerand ME, Jones J, Hermann B, Prabhakaran V, Adluru N, Struck AF.   +12 more
europepmc   +1 more source