Results 91 to 100 of about 15,605,882 (261)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mediators effecting moderate-to-vigorous physical activity and inactivity for girls from an intervention program delivered in an organised youth sport setting

, 2015
Objectives: The objective of this study was to test whether coaches' physical activity levels, contextual variables, and coaches' behavioural variables mediated the effect of an intervention on female basketball players' moderate-to-vigorous physical ...
Lonsdale, Chris, Rosenkranz, Richard R. (R15136), Parker, Philip D., Guagliano, Justin M., Kolt, Gregory S. (R11602), Agho, Kingsley E. (R13260)   +5 more
core   +1 more source

Menilik Reaksi Pasar Terhadap Pengumuman Rilis Fatwa MUI No. 83 Tahun 2023

Jurnal Riset dan Aplikasi: Akuntansi dan Manajemen
: Examining the Market Reaction to the Announcement of the Release of MUI Fatwa No. 83 Year 2023 Purpose: Revealing the market reaction that has an impact on the stimulus in the form of MUI's fatwa on the appeal not to use Israeli-affiliated products ...
Zakir Gunibala, Andini Renuat, Sukmawati Indah Dzikriah   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Reaksi Harga Saham Dan Informasi Non Ekonomi Pada Perusahaan Transportasi dan Pariwisata di Indonesia

Monex: Journal Research Accounting Politeknik Tegal
Tujuan penelitian ini untuk mengukur kemungkinan adanya perbedaan Abnormal Return dan Trading Volume Activity pada harga saham Bursa Efek Indonesia sektor transportasi dan pariwisata sebelum dan sesudah penerapan kebijakan penghapusan PPKM.
Ria Meilan, Deni Juliasari, M Wimbo Wiyono   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Exchange rate variability, market activity and heterogeneity [PDF]

We study the role played by geographic and bank-size heterogeneity in the relation between exchange rate variability and market activity. We find some support for the hypothesis that increases in short-term global interbank market activity, which can be ...
Dagfinn Rime, Genaro Sucarrat
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

PBMC telomerase activity correlates with hippocampal volume in major depression

European Journal of Psychotraumatology, 2012
The cellular enzyme elomerase replenishes telomeric DNA, which can be lost during repeated mitoses or during exposure to inflammation and oxidation. However, telomerase may have other, non-canonical functions, including (in animal models) antidepressant ...
Owen M. Wolkowitz, Synthia H. Mellon, Elizabeth H. Blackburn, Jue Lin, Elissa S. Epel, Victor I. Reus, Heather M. Burke, Rebecca Rosser, John Coetzee, Laura Mahan, Michelle Coy, Scott Mackin, Steven P. Hamilton, J. Craig Nelson, Michael W. Weiner, Susanne Mueller   +15 more
doaj   +1 more source