Results 51 to 60 of about 15,605,882 (261)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Atrial natriuretic factor (ANF) and renin-aldosterone in volume regulation of patients with cirrhosis [PDF]

, 1989
The role of the atrial natriuretic factor and of the main counteracting sodium-retaining principle, the renin-aldosterone system, in acute volume regulation of cirrhosis of the liver has been investigated.
Arendt, Rainer M., Paumgartner, Gustav, Wernze, Heinrich, Riedel, Angelika, Gerbes, Alexander L., Sauerbruch, Tilman   +5 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Results from the Netherlands' 2018 Report Card and Report Card+ on physical activity for children and youth with and without chronic medical condition

, 2020
Objective: The objective of this study was to summarize the results of the 2018 the Netherlands' Physical Activity Report Card (PARC) for children and youth as well as for children and youth with a chronic medical condition (CMC; PARC+).
Dutch Physical Activity Report Card Study Group
core  

Unraveling Market Shifts: A Study of Abnormal Returns, Trading Activity, and Volume Dynamics Around the COVID-19 Pandemic

Indonesian Interdisciplinary Journal of Sharia Economics
This study (case study on LQ-45 stocks on the Indonesia Stock Exchange) will examine the differences between these times to evaluate abnormal returns, trading frequency activity, and volume activity before and after the Covid-19 pandemic.
Mochammad Ilyas Junjunan, Adinda Angie Dwi Santoso, Binti Shofiatul Dwi Jannah, Muhammad Safdar   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Report Card Grades on the Physical Activity of Children and Youth Comparing 30 Very High Human Development Index Countries [PDF]

, 2018
BACKGROUND: To better understand the childhood physical inactivity crisis, Report Cards on physical activity of children and youth were prepared concurrently in 30 very high Human Development Index countries.
Tyler, Richard, Edwards, Lowri, Chang, Chen-Kang,, Smith, Melody,, Löf, Marie, Zembura, Pawel, Tammelin, Tuija, Skovgaard, Thomas; id_orcid, Aubert, Salomé, Katzmarzyk, Peter, Wong, Stephen H.S., Tammelin, Tuija,, Tanaka, Chiaki,, Delisle Nyström, Christine, Morrison, Shawnda, Chang, Chen Kang, Korcz, Agata, Kim, Yeon Soo, Zembura, Paweł, Schranz, Natasha, Skovgaard, Thomas,, Ibrahim, Izzeldin, Aubert, Salome,, Loney, Tom,, Williams, Alun,, Morrison, Shawnda A.,, Ibrahim, Izzeldin A. E.,, Lee, Eun-Young,, Edwards, Lowri Cerys, Scriven, John, Scriven, John,, Wong, Stephen H S, Ibrahim, Izzeldin A E, Tyler, Richard,, Tremblay, Mark S.,, Edwards, Lowri,, Jürimäe, Jaak, Seghers, Jan, Katzmarzyk, Peter T., Nystrom, Christine Delisle, Ibrahim, Izzeldin AE, Morrison, Shawnda A., Starc, Gregor,, Loney, Tom, Wong, Stephen HS, Barnes, Joel D., Roman-Vinas, Blanca,, Wong, Stephen, Katzmarzyk, Peter T.,, Mota, Jorge,, Tanaka, Chiaki, Barnes, Joel, Stratton, Gareth, Lee, Eun Young, Aguilar-Farias, Nicolas, Williams, Alun, Skovgaard, Thomas, Huang, Wendy Y.,, Reilly, John J., Standage, Martyn, Tremblay, Mark, Cardon, Greet,, Mota, Jorge, Tyler, Richard; id_orcid, Demetriou, Yolanda, Löf, Marie,, Aguilar-Farias, Nicolas,, Wong, Stephen H. S.,, Takken, Tim, Katzmarzyk, Peter T, Stratton, Gareth,, Schranz, Natasha,, Reilly, John J, Takken, Tim,, Barnes, Joel D.,, Emeljanovas, Arunas,, Tremblay, Mark S., Roman-Viñas, Blanca, Huang, Wendy, Ibrahim, Izzeldin A.E., Smith, Melody, Thivel, David,, Reilly, John J.,, Soo Kim, Yeon, Huang, Wendy Y, Chang, Chen-Kang, Reilly, John, Thivel, David, Starc, Gregor, Barnes, Joel D, Jurimae, Jaak,, Cardon, Greet, Emeljanovas, Arunas, Lee, Eun-Young, Seghers, Jan,, Standage, Martyn,, Kim, Yeon Soo,, Huang, Wendy Y., Gareth Stratton, Nystrom, Christine Delisle,, Tremblay, Mark S, Demetriou, Yolanda,, Morrison, Shawnda A, Zembura, Pawel,, Lowri Edwards, Korcz, Agata,, Gába, Aleš, Gaba, Ales,   +107 more
core   +2 more sources

Physical Activity Assessed by Wrist and Thigh Worn Accelerometry and Associations with Cardiometabolic Health

Sensors, 2023
Physical activity is increasingly being captured by accelerometers worn on different body locations. The aim of this study was to examine the associations between physical activity volume (average acceleration), intensity (intensity gradient) and ...
Benjamin D. Maylor, Charlotte L. Edwardson, Alexandra M. Clarke-Cornwell, Melanie J. Davies, Nathan P. Dawkins, David W. Dunstan, Kamlesh Khunti, Tom Yates, Alex V. Rowlands   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source