Results 61 to 70 of about 867,456 (263)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Evaluation of the volume and volume fraction of the lateral ventricles in the Parkinsonism
Journal of Experimental and Clinical Medicine, 2014 Parkinson’s disease (PD) commonly begins in late middle age and the course is slowly progressive. Ventricular enlargement, a nonspecific measure of brain atrophy, has been associated with PD. The aim of this study is to perform the measurements of the cerebral hemispheres and lateral ventricles using magnetic resonance imaging (MRI) in combination with
ACAR GÜDEK, Meltem +5 more
openaire +3 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Effect of Fuel Mass Flow at the End of Injection on Cavitation and Gas Ingestion in the Nozzle
Applied Sciences, 2020 The fuel flow in the diesel engine nozzle has a vital impact on the fuel atomization and spray, and the fuel mass flux affects the internal flow of the nozzle.
Hua Wen, Yulong Jiang, Jinglong Ma
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Effect of Volume Fraction of Epoxy Matrix Coconut Shell Composite on Tensile and Impact Loads
Engineering ProceedingsThis research aims to determine the effect of the volume fraction of coconut shell composite, with an epoxy matrix at 10% coconut shell water content, on the composite’s tensile strength, impact, density, and fracture results with the macrostructure. The
Agus Hariyanto +8 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
SPATIAL STATISTICS FOR SIMULATED PACKINGS OF SPHERES
Image Analysis and Stereology, 2011 This paper reports on spatial-statistical analyses for simulated random packings of spheres with random diameters. The simulation methods are the force-biased algorithm and the Jodrey-Tory sedimentation algorithm.
Alexander Bezrukov +2 more
doaj +1 more source