Results 81 to 90 of about 957,468 (265)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Volume fraction variations and dilation in colloids and granulars [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2009
I discuss the importance of spatial and temporal variations in particle volume fraction to understanding the force response of concentrated colloidal suspensions and granular materials.
openaire   +4 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Design of Structural Parameters of Liquid CO₂ Airtight Sand Blender

Shiyou jixie, 2018
Based on the Venturi principle, a CO2 airtight sand blender model was established. Under the given processing parameters like treatment volume and sand carrying ratio, the influences of three structural parameters-pipe diameter, pipe length and ...
Ma Weiguo, Mu Di, Peng Pingsheng
doaj  

On the kinetics of phase transformation of small particles in Kolmogorov's model

Condensed Matter Physics, 2008
The classical Kolmogorov-Johnson-Mehl-Avrami (KJMA) theory is generalized to the case of a finite-size system. The problem of calculating the new-phase volume fraction in a spherical domain is solved within the framework of geometrical-probabilistic ...
N.V. Alekseechkin
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Optimization of a New Static Mixer Based on CFD Simulation

Shiyou jixie, 2015
To meet the mixing requirements of crude oil desulfurization process,for fin type static mixer structure program,the inner flow fields of different structures have been simulated using computational fluid dynamics.Then,the fin type static mixer structure
Zhang Guofeng, Zhang Qin, Zhang Manlai, Zhou Zhihong, Cheng Li   +4 more
doaj  

Two-Phase Inclined MHD Blood Flow in Porous Tumor Region with Concentration and Volume Fraction

East European Journal of Physics
There are different approaches for treating invasive and non-invasive tumors. The flowing fluid (blood) provides the required nutrients to the tumors and absorbs the suspensions.
D. Kumar, M. Garvandha, S. Kumar, N. Deo
doaj   +1 more source

Equality Conditions for the Fractional Superadditive Volume Inequalities

Discrete & Computational Geometry
Abstract While studying set function properties of Lebesgue measure, F. Barthe and M. Madiman proved that Lebesgue measure is fractionally superadditive on compact sets in $$\mathbb {R}^n$$ R ...
openaire   +4 more sources