Results 91 to 100 of about 979,356 (312)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Effect of Volume Fraction of Epoxy Matrix Coconut Shell Composite on Tensile and Impact Loads

open access: yesEngineering Proceedings
This research aims to determine the effect of the volume fraction of coconut shell composite, with an epoxy matrix at 10% coconut shell water content, on the composite’s tensile strength, impact, density, and fracture results with the macrostructure. The
Agus Hariyanto   +8 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Effect of Fuel Mass Flow at the End of Injection on Cavitation and Gas Ingestion in the Nozzle

open access: yesApplied Sciences, 2020
The fuel flow in the diesel engine nozzle has a vital impact on the fuel atomization and spray, and the fuel mass flux affects the internal flow of the nozzle.
Hua Wen, Yulong Jiang, Jinglong Ma
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Gas volume fraction and velocity profiles: vertical and inclined bubbly air-water flows [PDF]

open access: yes
Upward inclined gas-liquid flows are frequently encountered in the oil industry and data relating to the local gas volume fraction distribution and the local gas velocity distribution is important, for example, in pressure gradient prediction and in ...
Lucas, Gary
core  

Free volume fraction and nanoholes shapes in polyvinyl acetate [PDF]

open access: yes, 2009
Positron annihilation lifetime and specific volume measurements were carried out in polyvinyl acetate, with the aim to evaluate the free volume fraction in a range of temperatures above the glass transition.
CONSOLATI, GIOVANNI   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Non-invasive velocity and volume fraction profile measurement in multiphase flows [PDF]

open access: yes
Multiphase flow is the simultaneous flow of two or more phases, in direct contact, and is important in the oil industry, e.g. in production wells, in sub-sea pipelines and during the drilling of wells.
Al-Hinai, Sulaiyam
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

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