Results 51 to 60 of about 4,089,988 (286)

Loading Dose of Ceftazidime Needs to Be Increased in Critically Ill Patients: A Retrospective Study to Evaluate Recommended Loading Dose with Pharmacokinetic Modelling

Antibiotics
To rapidly achieve ceftazidime target concentrations, a 2 g loading dose (LD) is recommended before continuous infusion, but its adequacy in critically ill patients, given their unique pharmacokinetics, needs investigation.
Manon Launay, Edouard Ollier, Benjamin Kably, Félicien Le Louedec, Guillaume Thiery, Julien Lanoiselée, Sophie Perinel-Ragey   +6 more
doaj   +1 more source

Revisiting the application of Immobilized Artificial Membrane (IAM) chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugs

ADMET and DMPK, 2020
Immobilized Artificial Membrane (IAM) chromatography columns have been used to model the in vivo distribution of drug discovery compounds. Regis Technologies Inc., the manufacturer, had to replace the silica support and consequently introduced a new IAM ...
Klara Livia Valko, Silvia Rava, Shenaz Bunally, Scott Anderson   +3 more
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

A Review of Therapeutic Agents Given by Convection-Enhanced Delivery for Adult Glioblastoma

Pharmaceuticals
Glioblastoma remains a devastating disease with a bleak prognosis despite continued research and numerous clinical trials. Convection-enhanced delivery offers researchers and clinicians a platform to bypass the blood–brain barrier and administer drugs ...
Nathaniel W. Rolfe, Nicholas B. Dadario, Peter Canoll, Jeffrey N. Bruce   +3 more
doaj   +1 more source

Volume and surface distribution of radiation defect in natural diamonds

Записки Горного института, 2018
In the following article, we have studied the variations of natural irradiation of diamond crystals. The natural diamonds in some cases show homogeneous green colour, caused by irradiation of the entire crystals volume. Radiation damage effects, produced
E. A. Vasil'ev, A. V. Kozlov, V. A. Petrovskii   +2 more
doaj   +1 more source

Relationship Between Acute Appendicitis and Platelet Indices in Childhood [PDF]

Journal of Pediatric Emergency and Intensive Care Medicine, 2018
Introduction: Appendicitis is the inflammation of the appendix vermiformis. Clinical diagnosis of acute appendicitis in children is still a problem.
Asena Sucu, Orkun Tolunay, İlknur Banlı Cesur, Zerrin Özçelik, Tamer Çelik, Salim Reşitoğlu, Ümit Çelik   +6 more
doaj   +1 more source

Distribution of the Volume of Weighted Gaussian Simplex [PDF]

arXiv, 2020
Let $X_0, \ldots, X_l$ be independent standard Gaussian vectors in $\mathbb{R}^d$ such that $l \leqslant d$. We derive an explicit formula for the distribution of the volume of weighted Gaussian simplex without the origin -- $l$-dimensional simplex $\mathrm{conv}(\sigma_0X_0, \ldots, \sigma_lX_l)$ ($\sigma_0, \ldots, \sigma_l > 0$).
arxiv  

Free Volume Power Law for Transport Properties of Hard Sphere Fluid [PDF]

, 2020
This paper presents a study on the relationship between transport properties and geometric free volume for hard sphere (HS) system in dense fluid region. Firstly, a generic free volume distribution function is proposed based on recent simulation results for the HS geometric free volume by Maiti et al.
arxiv   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source