Results 61 to 70 of about 4,089,988 (286)

Probability Models and Statistical Tests for Extreme Precipitation Based on Generalized Negative Binomial Distributions

open access: yesMathematics, 2020
Mathematical models are proposed for statistical regularities of maximum daily precipitation within a wet period and total precipitation volume per wet period.
Victor Korolev, Andrey Gorshenin
doaj   +1 more source

Distribution of volumes and coordination number in jammed matter: mesoscopic ensemble [PDF]

open access: yes, 2008
We investigate the distribution of the volume and coordination number associated to each particle in a jammed packing of monodisperse hard sphere using the mesoscopic ensemble developed in Nature 453, 606 (2008). Theory predicts an exponential distribution of the orientational volumes for random close packings and random loose packings.
arxiv   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Utility of renal replacement therapy in poisoning and drug overdosage

open access: yesJournal of Pediatric Critical Care
Toxic and prescribed drug ingestions are a significant cause of pediatric morbidity and mortality. Management of the poisoned patient begins with a thorough evaluation, identification of the agent(s) involved, and assessment of severity and symptoms ...
Rohit Bhowmick, Sasidaran Kandasamy
doaj   +1 more source

Analysis of Fiber Distribution and Volume Ratio of Unidirectional Composite for Micromodels [PDF]

open access: yesTransactions of the VŠB-Technical University of Ostrava, Mechanical Series, 2013
This work focuses on assessment of real fiber and matrix volume ratios of unidirectional fiber composites which will be used while designing corresponding micromodels.
Hana SRBOVÁ   +3 more
doaj   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Structure and Properties of High and Low Free Volume Polymers Studied by Molecular Dynamics Simulation

open access: yesComputation, 2019
Using molecular dynamics, a comparative study was performed of two pairs of glassy polymers, low permeability polyetherimides (PEIs) and highly permeable Si-containing polytricyclononenes.
Mikhail Mazo   +4 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Quantitative Structure – Pharmacokinetics Relationships Analysis of Basic Drugs: Volume of Distribution

open access: yesJournal of Pharmacy & Pharmaceutical Sciences, 2015
Purpose. The early prediction of pharmacokinetic behavior is of paramount importance for saving time and resources and for increasing the success of new drug candidates.
Zvetanka Dobreva Zhivkova   +2 more
doaj   +1 more source

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