Results 81 to 90 of about 5,814,761 (295)

Predicting the cosmological constant with the scale-factor cutoff measure

open access: yes, 2008
It is well known that anthropic selection from a landscape with a flat prior distribution of cosmological constant Lambda gives a reasonable fit to observation.
A. A. Starobinsky   +10 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Characteristics of Pore Volume Distribution and Methane Adsorption on Shales

open access: yesAdsorption Science & Technology, 2015
Shale pore structure has an important effect upon shale-gas adsorption. In order to quantify their contribution to the total amount of adsorbed gas, we investigate the pore volume distribution on shale, coal, isolated kerogen, and clay samples using low ...
Rui Wang   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Quantitative Structure – Pharmacokinetics Relationships Analysis of Basic Drugs: Volume of Distribution

open access: yesJournal of Pharmacy & Pharmaceutical Sciences, 2015
Purpose. The early prediction of pharmacokinetic behavior is of paramount importance for saving time and resources and for increasing the success of new drug candidates.
Zvetanka Dobreva Zhivkova   +2 more
doaj   +1 more source

Stochastic Generation of Particle Structures with Controlled Degree of Heterogeneity

open access: yes, 2010
The recently developed void expansion method (VEM) allows for an efficient generation of porous packings of spherical particles over a wide range of volume fractions. The method is based on a random placement of the structural particles under addition of
Filser, Frank T.   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

The Existence of Pair Potential Corresponding to Specified Density and Pair Correlation

open access: yes, 2009
Given a potential of pair interaction and a value of activity, one can consider the Gibbs distribution in a finite domain $\Lambda \subset \mathbb{Z}^d$.
A Lenard   +8 more
core   +1 more source

Home - About - Disclaimer - Privacy