Results 151 to 160 of about 167,853,838 (296)

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Critical import supply elasticities and the ‘imports-as-market-discipline’ hypothesis [PDF]

This paper formally examines the factors underlying how responsive imports must be to domestic prices (the ‘import supply elasticity’) in order to thwart an anticompetitive domestic price increase stemming from a merger––an issue that frequently arises ...
Zimmerman, Paul R., Carlson, Julie A.
core  

Reflections of the trade-led-growth hypothesis on the Nepalese economy

المجلة الدولية للأداء الاقتصادي
This study examines the effect of foreign trade on Nepal's economic growth. It comprises export, import, and total foreign trade volume as economic growth determinants.
Arjun Kumar Dahal, Khagendra Kumar Thapa
doaj  

Hydrophobic interactions of FG-nucleoporins are required for dilating nuclear membrane pores into selective transport channels after mitosis. [PDF]

Nat Struct Mol Biol
Zhang W, Latham AP, Ronchi P, Schnorrenberg S, Hériché JK, Huang Z, Sue C, Hossain MJ, Morero NR, Pflaumer H, Hantsche-Grininger M, Schwab Y, Sali A, Ellenberg J.   +13 more
europepmc   +1 more source

USP30-Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease. [PDF]

Adv Sci (Weinh)
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Li J, Hua C, Li G, Zhai F, Ren J, Pan S, Feng Q, Wen J, Liu D, Liu Z, Duan J.   +10 more
europepmc   +2 more sources

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

Advanced Science, EarlyView.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen, Ming‐Ying Xiao, Lan‐Lan Guo, Hao‐Yue Hu, Sui‐Xian Zhang, Bai‐Qiang Dong, Chen‐Fei Wu, Xia‐Hang Huang, Li Li, Run‐Zhe Chen, Yuan‐Yang Huang, Ying Jin, Hai Song, Ying Wang, Qi‐Wen Li, Ming Chen, Xuan Li, Yuan‐Yuan Chen   +17 more
wiley   +1 more source

AN EMPIRICAL ESTIMATION OF THE IMPORT DEMAND MODEL AND WELFARE EFFECTS: THE CASE OF RICE IMPORTING COUNTRIES [PDF]

This analysis presents the determination of an import demand function for the world rice market using annual data from 1994 to 2007. In the specification and analysis of a world rice market import demand function, Ordinary Least Square (OLS ...
Kennedy, P. Lynn, Hilbun, Brian M., Kang, Hyunsoo   +2 more
core  

A comprehensive analysis of China's plum industry: production dynamics, trade imbalances, technological innovation, and future directions. [PDF]

Front Plant Sci
Xu Y, Zhang Z, Zhao H, Wang B, Hao Y, Sui S, Zhang Y, Xu M, Zhang Y, Ma X, Liu J, Liu J, Fang B, Chen H, Zhang Y, Liu C, Wu J, Sun H, Li T, Liu W, Liu S.   +20 more
europepmc   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Foreign Trade Regimes and Import Demand Function: Evidence from Sri Lanka [PDF]

Time series data for Sri Lanka span periods of pervasive trade and exchange restrictions along with periods of liberalized trade. This paper implements a structural econometric model of aggregate imports which incorporates the implications of the shifts ...
M. Shahe Emran, Forhad Shilpi
core