Results 111 to 120 of about 5,853,808 (330)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Breast Tissue 3D Segmentation and Visualization on MRI

International Journal of Biomedical Imaging, 2013
Tissue segmentation and visualization are useful for breast lesion detection and quantitative analysis. In this paper, a 3D segmentation algorithm based on Kernel-based Fuzzy C-Means (KFCM) is proposed to separate the breast MR images into different ...
Hong Song, Xiangfei Cui, Feifei Sun
doaj   +1 more source

A virtual workspace for hybrid multidimensional scaling algorithms [PDF]

, 2003
In visualising multidimensional data, it is well known that different types of algorithms to process them. Data sets might be distinguished according to volume, variable types and distribution, and each of these characteristics imposes constraints upon ...
Chalmers, M., Ross, G.
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Visualizing Bags of Vectors [PDF]

, 2013
The motivation of this work is two-fold - a) to compare between two different modes of visualizing data that exists in a bag of vectors format b) to propose a theoretical model that supports a new mode of visualizing data.
Balasubramanian, Sriramkumar, Nagireddy, Raghuram Reddy   +1 more
core  

Evaluation of gesture based interfaces for medical volume visualization tasks

International Conference on Virtual Reality Continuum and its Applications in Industry, 2011
Physicians are accustomed to using volumetric datasets for medical assessment, diagnosis and treatment. These modalities can be displayed with 3D computer visualizations for physicians to study the overall shape and internal anatomical structures ...
C. Kirmizibayrak, Nadezhda Radeva, M. Wakid, John Philbeck, J. Sibert, J. Hahn   +5 more
semanticscholar   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Advancing Progressive Web Applications to Leverage Medical Imaging for Visualization of Digital Imaging and Communications in Medicine and Multiplanar Reconstruction: Software Development and Validation Study

JMIR Medical Informatics
BackgroundIn medical imaging, 3D visualization is vital for displaying volumetric organs, enhancing diagnosis and analysis. Multiplanar reconstruction (MPR) improves visual and diagnostic capabilities by transforming 2D images ...
Mohammed A. AboArab, Vassiliki T. Potsika, Alexis Theodorou, Sylvia Vagena, Miltiadis Gravanis, Fragiska Sigala, Dimitrios I. Fotiadis   +6 more
doaj   +1 more source

A Fast 3D Brain Extraction and Visualization Framework Using Active Contour and Modern OpenGL Pipelines

IEEE Access, 2019
Brain extraction is a process of removing non-brain tissue in the brain magnetic resonance (MR) images and serves as a first step towards more delicate brain segmentation.
Junchen Wang, Zhen Sun, Honglei Ji, Xiaohui Zhang, Tianmiao Wang, Yu Shen   +5 more
doaj   +1 more source