Results 131 to 140 of about 2,687,345 (274)

Intention to voluntary blood donation among private higher education students, Jimma town, Oromia, Ethiopia: Application of the theory of planned behaviour. [PDF]

PLoS One, 2021
Aschale A, Fufa D, Kekeba T, Birhanu Z.
europepmc   +1 more source

Factors that lead the voluntary blood donor to make the donation

, 2022
Hemotherapy is a form of treatment for various pathologies or for victims of trauma. Even with the evolution of science and technology, there is nothing that can replace blood tissue. To maintain the quality standard of donated blood, it is necessary to avoid as much as possible donations when someone in the family needs it.
Rodrigues, Hanna Monise Soares, Silveira , Herycle Victor Nunes, Leão , Natallia Moreira Lopes, Franco, Jéssyka Viana Valadares, Barbosa, Juliana Marinho, Labre, Thiago Brilhante Pereira, Miglioli, João Vitor Brito, Silva , Ana Laura Germano da, Chagas , Renata Ferreira, Rodrigues , Rayssa Soares   +9 more
openaire   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Knowledge, attitude and practice toward blood donation and associated factors among college students in Jumla, Nepal

Discover Public Health
Background Blood donation is a vital component of modern healthcare systems, as blood cannot yet be fully synthesized for routine clinical use and depends entirely on voluntary human donors.
Deependra Muraw, Nisha Adhikari, Pradeep Narayan Joshi, Dirgha Raj Joshi   +3 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Enhancing voluntary blood donations: King Fahad Armed Forces Hospital experience with mobile donation campaign

Frontiers in Public Health
BackgroundBlood donation is crucial for healthcare systems worldwide, ensuring the availability of blood and its products for patients in need. Many regions struggle to maintain adequate blood supplies due to reliance on patient-related donations ...
Waleed M. Bawazir, Waleed M. Bawazir, Osama A. Alzahrani, Ahmed G. Bukhari, Ahmed G. Bukhari, Raed I. Felimban, Raed I. Felimban, Waseem A. Alsolaimi, Naif A. Algarni, Abdulaziz A. Albarqi, Mohammed S. Alzahrani, Nabeel S. Sendi, Junaid H. Faqih, Shaza M. Al-Hindi, Mohammad H. Alhashmi, Mohammad H. Alhashmi, Hadeel Al Sadoun, Hadeel Al Sadoun, Saeed M. Kabrah, Wajnat A. Tounsi, Nora Y. Hakami   +20 more
doaj   +1 more source

Recoding the gift relationship: views on introducing genomic testing to blood donation

This study examines how the institutional context informs the ways in which healthy recipients relate to genomic information. Through focus group data, it considers the trend of blood collection agencies (BCA) moving to extend donor genotyping.
Vera Raivola, Barbara Masser, Rachel Thorpe, Masser, Barbara, Thorpe, Rachel, Raivola, Vera   +5 more
core   +1 more source

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li, Jia Deng, Lin Sun, Shihui Wang, Huizhi Li, Jing Chen, Lipan Zhao, Xilin Shen, Yan Sun   +8 more
wiley   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source