Results 131 to 140 of about 2,942,603 (300)

Study on Screening Tests among the Blood Donors in Dhaka Medical College Hospital, Bangladesh

, 1970
Context: Most deaths caused by transfusion worldwide is due to transmission of infectious agents like Virus, Bacteria and Protozoa. The risk of disease transmission increases many fold if blood donor selection is inappropriate (such as blood from ...
MAE Siddiqui, HA Begum, FS Chowdhury, MM Hoque, MZ Hossain, SD Adnan   +5 more
core   +1 more source

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

Voluntary Blood Donation in Modern Healthcare: Trends, Challenges, and Opportunities

Epidemiologia
Voluntary blood donation plays a crucial role in public health by ensuring a stable supply of blood and its components, essential for medical treatments including surgeries, trauma care, and chronic disease management.
Svjetlana Gasparovic Babic, Antea Krsek, Lara Baticic   +2 more
doaj   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Prevalence of select micronutrient deficiencies in Indian voluntary blood donors

Asian Journal of Transfusion Science
Abstract INTRODUCTION: Frequent and regular blood donation is associated with iron deficiency and iron depletion in apparently healthy individuals. However, besides iron, water-soluble vitamins and folate play a significant role in regulating hemoglobin erythropoiesis.
Chavan, Preeti, Ojha, Shashank, Bhat, Vivek, Poojary, Minal, Sharma, Nikita, Kannan, Sadhana, Pillai, Babu, Pal, Sanjay, Sathyan, Vimal, Gupta, Sudeep   +9 more
openaire   +2 more sources

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

[News Clip: Blood donor]

, 1959
Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about Fort Worth resident, Marlene Griffin, donating blood every two months since ...
WBAP-TV (Television station : Fort Worth, Tex.)
core   +1 more source

Anti HCV seroprevalence among the voluntary blood donors in Thailand

Hematology, 2005
Hepatitis C virus (HCV) infection is an increasing problem, affecting large numbers of the population in both the developed and the developing parts of the world. It is generally accepted as a significant public health problem with major associated morbidities and mortalities, in particular hepatocellular carcinoma.
openaire   +2 more sources

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source