Results 121 to 130 of about 2,942,603 (300)

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Motivating factors of voluntary blood donors

Liječnički vjesnik : glasilo Hrvatskog liječničkog zbora. Suplement, 2017
Davanje krvi, s praktičnoga stajališta, zanimljivo je ponašanje jer je neupitno korisno, a uspješno bi predviđanje davanja krvi otvorilo putove k regrutaciji novih i zadržavanju postojećih davatelja. Ako smo svjesni činjenice da oko 60% osoba nema zdravstvenih zapreka za davanje krvi, a da samo 3% - 5% redovito daje krv, te da su istodobno potrebe za ...
openaire   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

[Australia antigen in voluntary blood donors].

Mikrobiyoloji bulteni, 1976
35.370 blood samples, collected from woluntary blood donors by the Blood Transfusion Services of the Turkish Red Crescent Society in one year, were tested by the systematic screening CEP Method for the "Au" antigen, according to the recommendations of WHO. The number and percentage of positive "Au" antigen cases are shown in Table 1.
openaire   +1 more source

Viral Infectivity Markers in Donor Blood: A Retrospective Study of Three Donor Categories

, 2004
A total of 12,540 homologous donors seen between 1993 and 1999 at the University of Maiduguri Teaching Hospital (U.M.T.H) blood bank were analysed with respect to the frequency of viral infectivity markers (HBsAg and HIV antibodies) as it relates to ...
Ahmed, S.G., Hassan, A. W.
core   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Prediction model of the number of street voluntary blood donors

Zhongguo shuxue zazhi, 2022
Objective To explore the relationship between climate factors and the number of street voluntary blood donors in Beijing and develop a reliable predictive model, so as to provide reference for donor recruitment. Methods The data of weather and the number of street blood donors from January 2018 to October 2019 were collected to formulate generalized ...
Qiyong BI, Zhili WANG, Xiao CHEN
openaire   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

High proportions of iron deficiency and thalassemia in blood donors with low RBC osmotic fragility: a call for targeted public health responses in Southern China

Frontiers in Public Health
ObjectiveThis study aimed to investigate the prevalence and etiological profile of decreased red blood cell osmotic fragility among voluntary blood donors in Shenzhen, China, and to assess the public health implications for donor screening policies and ...
L. Y. Sun, R. Li, D. H. He, Z. S. Xie, C. L. Liang, S. Q. Cai, J. F. Zeng, S. X. Wang   +7 more
doaj   +1 more source

Analysis of red blood cell blood group gene polymorphism and applicability evaluation of PCR-TaqMan technology in the Hui ethnic blood donor population in Suzhou

[Objective] To investigate the characteristics of allele frequencies for 9 red blood cell (RBC) blood group systems in the Hui ethnic voluntary blood donor population of Suzhou using real-time fluorescence PCR technology, so as to provide technical ...
JIANG Nina, JIANG Jia, FANG Zhihong, WANG Kai, XU Zihao   +4 more
core   +1 more source