Results 81 to 90 of about 3,395 (297)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Investigation of volute geometry on pressure distribution in impeller casing
, 2003 The present work focuses on the investigation of the effect of the volute geometry, especially, the volute profile, radial clearance and volute tongue position on the circumferential pressure distribution and the magnitude of imbalanced radial force.
Hu, Wei
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Advances in Mechanical Engineering, 2014 This paper presents an investigation of pressure fluctuation of a single-suction volute-type centrifugal pump, particularly volute casing, by using numerical and experimental methods.
Qiaorui Si +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2015 Volute Krater. last [?]tr of 4 cent BC. Getty Mus. Apulian Orpheus plays kithat=ra before hades + persephone. His music persuaded gods to allow return of Eurydice.
Ferguson, Everett
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Numerical simulation of impeller-volute interaction in centrifugal compressors.
, 1998 peer reviewedA numerical procedure to predict the impeller–volute interaction in a single-stage centrifugal compressor is presented. The method couples a three-dimensional unsteady flow calculation in the impeller with a three-dimensional time-averaged ...
Hillewaert, Koen +4 more
core +1 more source
Influence of the volute cross-sectional shape on mixed inflow turbine performances
Advances in Mechanical Engineering, 2017 The volute is an essential element in the centrifugal machines. Improving its performance is an effective way to improve the total performance of the turbine.
Mohamed Amine Meghnine +2 more
doaj +1 more source
Journal of the Malacological Society of Australia, 1957 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Impeller Volute and Diffuser Interaction
, 2006 The flow in centrifugal pumps is exceedingly complex, involving curvature, system rotation, separation, turbulence, and secondary flows. Moreover, the geometry is often asymmetric due to the volute shape. As a result, the relative motion between impeller
PAVESI, GIORGIO
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