Results 61 to 70 of about 5,631,965 (202)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, Volume 73, Issue S4, October 2026.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Excision of bilateral pheochromocytomas followed by staged resection of neuroendocrine carcinoma of the pancreas

Journal of Pediatric Surgery Case Reports, 2020
Pheochromocytoma (PCC) and Pancreatic Neuroendocrine tumor (PNET) occurring together have been considered as a spectrum of Von Hippel Lindau (VHL) Syndrome and carries a grave prognosis.
Sandesh V. Parelkar, Rujuta S. Shah, Sanjay N. Oak, Beejal V. Sanghvi, Gayatri Munghate, Satej S. Mhaskar, D.V. Kulkarni, Rahul Kumar Gupta, Kedar P. Mudkhedkar, Deepa P. Makhija, K.K. Khidtta   +10 more
doaj   +1 more source

Hepatic HIF2α Modulates Extra‐Hepatic Disease‐Associated Phenotypes During Metabolic Dysfunction‐Associated Steatotic Liver Disease

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
High fat, high fructose, high cholesterol “GAN” diet feeding in mice induces MASLD, cardiac dysfunction, loss of lean mass, and hyperinsulinaemia. Hepatocyte‐specific deletion of HIF2α also causes cardiac dysfunction and loss of lean mass but prevents GAN induced hyperinsulinaemia and cardiac sympathetic dominance without preventing MASLD.
Lorenz M. W. Holzner, Rosa M. Korpershoek, Youguo Niu, Anna Cochrane, Paula M. Darwin, Julia Babuta, Areesha Nazeer, Cecilia Castro, Alice P. Sowton, Alice E. Knapton, Benjamin D. Thackray, Julian L. Griffin, Zoe Hall, Dino A. Giussani, Rob C. I. Wüst, Andrew J. Murray   +15 more
wiley   +1 more source

Tratamiento farmacológico de las neoplasias asociadas con la enfermedad de von Hippel-Lindau. Revisión Sistemática

Oncología
Background: Von Hippel-Lindau disease is an autosomal dominant syndrome characterized by the development of benign and malignant tumors throughout life.
Veronica Hurtado Hurtado, Cristina Cabrera Mañay, Patricia Tamayo Aguilar   +2 more
doaj   +1 more source

Tympanostomy Tube Placement: The Effect of Location on Tube Retention and Risk of Perforation

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 5, October 2026.
Study examined the effect of tympanostomy tubes placed in the anterior‐inferior quadrant versus the posterior‐inferior quadrant. The study investigated if there was a difference in risk of early extrusion and risk of tympanic membrane perforation based on tube location.
Jason G. May, Eric Y. Du, Jacob A. Thoenen, Eliav Gov‐Ari, Arnaldo L. Rivera   +4 more
wiley   +1 more source

Glutamine Metabolism in Health and Diseases

MedComm, Volume 7, Issue 10, October 2026.
Glutamine metabolism acts as a metabolic hub connecting cellular stress adaptation, immune regulation, and disease development. Through regulating energy production, biosynthesis, redox balance, and nitrogen metabolism, glutamine supports cellular homeostasis under physiological and pathological conditions.
Yi Ding, Fan Tong, Jing Zeng, Chun‐Ping Cui   +3 more
wiley   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Von Hippel- Lindau syndrome (case report)

, 1990
Von Hippel-Lindau (VHL) sendromu nadir görülen heredofamilyal bir hastalıktır. Klasik bulgulan retinatla anjiomlar ve serebellumda hemanjioblastomlardır.

core  

Genotype-phenotype relations of the von Hippel-Lindau tumor suppressor inferred from a large-scale analysis of disease mutations and interactors.

PLoS Computational Biology, 2019
Familiar cancers represent a privileged point of view for studying the complex cellular events inducing tumor transformation. Von Hippel-Lindau syndrome, a familiar predisposition to develop cancer is a clear example.
Giovanni Minervini, Federica Quaglia, Francesco Tabaro, Silvio C E Tosatto   +3 more
doaj   +1 more source

Early-Onset Isolated Bilateral Pheochromocytoma As a Major Clinical Manifestation of von-Hippel Lindau Syndrome Type 2C

Journal of Pediatric Research, 2018
Pheochromocytoma is a rare disease that is characterized by the increased production and secretion of catecholamines from the adrenal medulla. The disease is autosomal dominant, and frequently sporadic and unilateral. Pheochromocytoma, which is diagnosed
Sezer Acar, Hale Tuhan, Korcan Demir, Ayça Aykut, Asude Durmaz, Ünal Utku Karaarslan, Gözde İnci, Oğuz Ateş, Ece Böber, Ayhan Abacı   +9 more
doaj   +1 more source