Results 101 to 110 of about 78,503 (229)

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Von Willebrand disease: classification and epidemiology. [PDF]

Haematologica
Castaman G, Bramante Federici A.
europepmc   +1 more source

Impaired nitric oxide‐dependent endothelial function in young male individuals with obesity before the onset of symptoms and complications

Experimental Physiology, EarlyView.
Abstract Endothelial dysfunction drives obesity‐related complications. Doppler ultrasound measurement of blood flow during 1‐min passive leg movements (PLM) is a valuable non‐invasive tool for assessing endothelial function and nitric oxide (NO)‐mediated vasodilation.
Lucrezia Zuccarelli, Giovanni Baldassarre, Adele Bondesan, Diana Caroli, Roberta De Micheli, Gabriella Tringali, Thomas Favaretto, Joanna Suraj‐Prazmowska, Anna Kurpinska, Joanna Majerczak, Stefan Chlopicki, Jerzy A. Zoladz, Alessandro Sartorio, Bruno Grassi   +13 more
wiley   +1 more source

Diagnosis of von Willebrand disease. [PDF]

Blood Adv
Bowman M, James P.
europepmc   +1 more source

The RhoA guanine exchange factor ABR: a glucose‐sensitive mediator of actin reorganization in feto‐placental arterial endothelial cells altered by gestational diabetes mellitus

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of proposed relationship between hyperglycaemia, gestational diabetes mellitus (GDM), active BCR‐related (ABR), RhoA and actin organization of feto‐placental arterial endothelial cells (fpEC). Hyperglycaemia upregulates ABR, which in turn increases RhoA activation.
Silvija Tokic, Boris Novakovic, Barbara Leopold‐Posch, Magdalena Mühlberger, Denise Hoch, Jelena Lögl, Eva M. Bernhart, Richard Saffery, Gernot Desoye, Ursula Hiden   +9 more
wiley   +1 more source

Clinical and laboratory diagnosis of von Willebrand disease. [PDF]

Haematologica
Tosetto A, Eikenboom J.
europepmc   +1 more source

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

American Journal of Medical Genetics Part A, Volume 200, Issue 3, Page 661-672, March 2026.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim, Alexsandra Christianne Malaquias, Debora Romeo Bertola, Raissa Carneiro Rezende, Laurana De Polli Cellin, Lucas Vieira Lacerda Pires, Ana Maria Santillan‐Vasconez, Antônio Marcondes Lerario, Renata da Cunha Scalco, Alexander Augusto de Lima Jorge   +9 more
wiley   +1 more source

Experimental infection of horses with African horse sickness virus results in overt disseminated intravascular coagulation

Equine Veterinary Journal, Volume 58, Issue 2, Page 619-629, March 2026.
Abstract Background African horse sickness (AHS), caused by the vector‐borne African horse sickness virus (AHSV), is endemic to sub‐Saharan Africa and infection results in high mortality in naïve equine populations. Clinical signs include submucosal petechiae and prolonged bleeding post venepuncture indicative of hypocoagulation.
Eva Christina Schliewert, Emma H. Hooijberg, Amelia Goddard   +2 more
wiley   +1 more source

Historical, current and future treatments for von Willebrand disease. [PDF]

Haematologica
Casari C, Leebeek FWG, Peyvandi F.
europepmc   +1 more source

ROC‐325 Attenuates Hypoxia‐Induced Pulmonary Hypertension Through Dual Inhibition of Autophagy and Hypoxia‐Inducible Factor 2α Signaling

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
In hypoxia‐induced pulmonary hypertension, endothelial HIF‐2α accumulation and autophagic activation drive vascular remodeling. We demonstrate that the novel lysosomal inhibitor ROC‐325 simultaneously attenuates this pathogenic autophagy and promotes HIF‐2α degradation.
Changlei Bao, Shuxin Liang, Dingyuan Liu, Xingting Wang, Dan Bai, Chuangjia Huang, Hanliang Sun, Zi Yang, Bitao Wu, Zixuan Chen, Jieyi Feng, Zinan Luo, Jintao Long, Jinsheng Zhu, June Bai, Li Zhang, Aiai Chu, Caojin Zhang, Haiyang Tang   +18 more
wiley   +1 more source